RT Journal Article
T1 Role of Leptin in the Activation of Immune Cells
A1 Fernández-Riejos, Patricia
A1 Najib, Souad
A1 Santos-Alvarez, Jose
A1 Martín-Romero, Consuelo
A1 Pérez-Pérez, Antonio
A1 González-Yanes, Carmen
A1 Sánchez-Margalet, Víctor
K1 atherosclerosis
K1 Leptin
K1 tejido adiposo
K1 adipocinas
K1 ateroesclerosis
K1 leptina
AB Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of metabolism and energy homeostasis. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone leptin has been shown to regulate the immune response, innate and adaptive response, both in normal and pathological conditions. The role of leptin in regulating immune response has been assessed in vitro as well as in clinical studies. It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility. Conversely, immune-mediated disorders such as autoimmune diseases are associated with increased secretion of leptin and production of proinflammatory pathogenic cytokines. Thus, leptin is a mediator of the inflammatory response
PB Hindawi Publishing Corporation
SN 0962-9351
YR 2010
FD 2010-03-23
LK http://hdl.handle.net/10668/375
UL http://hdl.handle.net/10668/375
LA en
NO Fernández-Riejos P, Najib S, Santos-Alvarez J, Martín-Romero C, Pérez-Pérez A, González-Yanes C, et al. Role of Leptin in the Activation of Immune Cells. Mediators Inflamm. 2010 (2010): Article ID 568343
NO Review Article
DS RISalud
RD Apr 19, 2025