RT Journal Article T1 Effect of comorbidities on long-term outcomes of colorectal cancer patients. A1 Quintana, José M A1 Anton-Ladislao, Ane A1 Lázaro, Santiago A1 Gonzalez, Nerea A1 Bare, Marisa A1 Fernandez-de-Larrea, Nerea A1 Redondo, Maximino A1 Escobar, Antonio A1 Sarasqueta, Cristina A1 Garcia-Gutierrez, Susana A1 Aguirre, Urko A1 REDISSEC-CARESS/CCR group, K1 colorectal cancer K1 comorbidity K1 outcomes K1 prospective cohort AB The objective of this work is to evaluate the association of comorbidities with various outcomes in patients diagnosed with colon or rectal cancer. We conducted a prospective cohort study of patients diagnosed with colon or rectal cancer who underwent surgery. Data were gathered on sociodemographic, clinical characteristics, disease course, and the EuroQol EQ-5D and EORTC QLQ-C30 scores, up to 5 years after surgery. The main outcomes of the study were mortality, complications, readmissions, reoperations, and changes in PROMs up to 5 years. Multivariable multilevel logistic regression models were used in the analyses. Mortality at some point during the 5-year follow-up was related to cardiocerebrovascular, hemiplegia and/or stroke, chronic obstructive pulmonary disease (COPD), diabetes, cancer, and dementia. Similarly, complications were related to cardiovascular disease, COPD, diabetes, hepatitis, hepatic or renal pathologies, and dementia; readmissions to cardiovascular disease, COPD, and hepatic pathologies; and reoperations to cerebrovascular and diabetes. Finally, changes in EQ-5D scores at some point during follow-up were related to cardiocerebrovascular disease, COPD, diabetes, pre-existing cancer, hepatic and gastrointestinal pathologies, and changes in EORTC QLQ-C30 scores to cardiovascular disease, COPD, diabetes, and hepatic and gastrointestinal pathologies. Optimising the management of the comorbidities most strongly related to adverse outcomes may help to reduce those events in these patients. YR 2022 FD 2022-02-16 LK http://hdl.handle.net/10668/19943 UL http://hdl.handle.net/10668/19943 LA en DS RISalud RD Feb 16, 2025