RT Journal Article
T1 Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
A1 Baglietto-Vargas, David
A1 Sánchez-Mejias, Elisabeth
A1 Navarro, Victoria
A1 Jimenez, Sebastián
A1 Trujillo-Estrada, Laura
A1 Gómez-Arboledas, Angela
A1 Sánchez-Mico, Maria
A1 Sánchez-Varo, Raquel
A1 Vizuete, Marisa
A1 Dávila, José Carlos
A1 García-Verdugo, José Manuel
A1 Vitorica, Javier
A1 Gutierrez, Antonia
AB Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer's patients. In this regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells suggests that hippocampal neurogenesis impairment is an important factor underlying these cognitive deficits. However, because of conflicting results, the impact of Aβ pathology on neurogenesis/gliogenesis remains unclear. Here, we investigated the effect of Aβ on neuronal and glial proliferation by using an APP/PS1 transgenic model and in vitro assays. Specifically, we showed that neurogenesis is affected early in the APP/PS1 hippocampus, as evidenced by a significant decrease in the proliferative activity due to a reduced number of both radial glia-like neural stem cells (type-1 cells) and intermediate progenitor cells (type-2 cells). Moreover, we demonstrated that soluble Aβ from APP/PS1 mice impairs neuronal cell proliferation using neurosphere cultures. On the other hand, we showed that oligomeric Aβ stimulates microglial proliferation, whereas no effect was observed on astrocytes. These findings indicate that Aβ has a differential effect on hippocampal proliferative cells by inhibiting neuronal proliferation and triggering the formation of microglial cells.
YR 2017
FD 2017-08-30
LK http://hdl.handle.net/10668/11543
UL http://hdl.handle.net/10668/11543
LA en
DS RISalud
RD Apr 9, 2025