TY  - JOUR
AU  - Chen, Zhongbo
AU  - Zhang, David
AU  - Reynolds, Regina H
AU  - Gustavsson, Emil K
AU  - García-Ruiz, Sonia
AU  - D'Sa, Karishma
AU  - Fairbrother-Browne, Aine
AU  - Vandrovcova, Jana
AU  - International Parkinson’s Disease Genomics Consortium (IPDGC)
AU  - Hardy, John
AU  - Houlden, Henry
AU  - Gagliano Taliun, Sarah A
AU  - Botía, Juan
AU  - Ryten, Mina
PY  - 2021
DO  - 10.1038/s41467-021-22262-5
UR  - https://hdl.handle.net/10668/26219
T2  - Nature communications
AB  - Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions simultaneously depleted for genetic...
LA  - en
KW  - Alzheimer Disease
KW  - Apolipoproteins E
KW  - Brain
KW  - Chromosomes, Human, Pair 19
KW  - Conserved Sequence
KW  - DNA, Intergenic
KW  - Gene Ontology
KW  - Genome, Human
KW  - Humans
KW  - Introns
KW  - Linkage Disequilibrium
KW  - Molecular Sequence Annotation
KW  - Neurodegenerative Diseases
KW  - Phenotype
KW  - Phylogeny
KW  - Polymorphism, Single Nucleotide
KW  - RNA, Long Noncoding
KW  - RNA, Messenger
KW  - Regression Analysis
TI  - Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.
TY  - research article
VL  - 12
ER  -