TY  - JOUR
AU  - Eslam, Mohammed
AU  - McLeod, Duncan
AU  - Kelaeng, Kebitsaone Simon
AU  - Mangia, Alessandra
AU  - Berg, Thomas
AU  - Thabet, Khaled
AU  - Irving, William L
AU  - Dore, Gregory J
AU  - Sheridan, David
AU  - Grønbæk, Henning
AU  - Abate, Maria Lorena
AU  - Hartmann, Rune
AU  - Bugianesi, Elisabetta
AU  - Spengler, Ulrich
AU  - Rojas, Angela
AU  - Booth, David R
AU  - Weltman, Martin
AU  - Mollison, Lindsay
AU  - Cheng, Wendy
AU  - Riordan, Stephen
AU  - Mahajan, Hema
AU  - Fischer, Janett
AU  - Nattermann, Jacob
AU  - Douglas, Mark W
AU  - Liddle, Christopher
AU  - Powell, Elizabeth
AU  - Romero-Gomez, Manuel
AU  - George, Jacob
AU  - International Liver Disease Genetics Consortium (ILDGC)
PY  - 2017
DO  - 10.1038/ng.3836
UR  - http://hdl.handle.net/10668/11076
T2  - Nature genetics
AB  - Genetic variation in the IFNL3-IFNL4 (interferon-λ3-interferon-λ4) region is associated with hepatic inflammation and fibrosis. Whether IFN-λ3 or IFN-λ4 protein drives this association is not known. We demonstrate that hepatic inflammation, fibrosis...
LA  - en
KW  - Fibrosis
KW  - Gene Frequency
KW  - Genotype
KW  - Haplotypes
KW  - Hepacivirus
KW  - Hepatitis C
KW  - Humans
KW  - Inflammation
KW  - Interferons
KW  - Interleukins
KW  - Linkage Disequilibrium
KW  - Liver
KW  - Logistic Models
KW  - Multivariate Analysis
KW  - Polymorphism, Single Nucleotide
KW  - Reverse Transcriptase Polymerase Chain Reaction
TI  - IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.
TY  - research article
VL  - 49
ER  -