RT Journal Article
T1 The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer.
A1 Garcia-Hernandez, Laura
A1 Garcia-Ortega, Maria Belen
A1 Ruiz-Alcala, Gloria
A1 Carrillo, Esmeralda
A1 Marchal, Juan Antonio
A1 Garcia, Maria Angel
K1 MAPK
K1 biomarkers
K1 cancer
K1 isoforms
K1 kinases
K1 p38
K1 therapy
AB The mitogen-activated protein kinase (MAPK) family is an important bridge in the transduction of extracellular and intracellular signals in different responses at the cellular level. Within this MAPK family, the p38 kinases can be found altered in various diseases, including cancer, where these kinases play a fundamental role, sometimes with antagonistic mechanisms of action, depending on several factors. In fact, this family has an immense number of functionalities, many of them yet to be discovered in terms of regulation and action in different types of cancer, being directly involved in the response to cancer therapies. To date, three main groups of MAPKs have been identified in mammals: the extracellular signal-regulated kinases (ERK), Jun N-terminal kinase (JNK), and the different isoforms of p38 (α, β, γ, δ). In this review, we highlight the mechanism of action of these kinases, taking into account their extensive regulation at the cellular level through various modifications and modulations, including a wide variety of microRNAs. We also analyze the importance of the different isoforms expressed in the different tissues and their possible role as biomarkers and molecular targets. In addition, we include the latest preclinical and clinical trials with different p38-related drugs that are ongoing with hopeful expectations in the present/future of developing precision medicine in cancer.
PB MDPI AG
YR 2021
FD 2021-12-27
LK http://hdl.handle.net/10668/21129
UL http://hdl.handle.net/10668/21129
LA en
NO García-Hernández L, García-Ortega MB, Ruiz-Alcalá G, Carrillo E, Marchal JA, García MÁ. The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer. Int J Mol Sci. 2021 Dec 29;23(1):370.
DS RISalud
RD Apr 5, 2025