RT Journal Article
T1 Lower levels of uric acid and striatal dopamine in non-tremor dominant Parkinson's disease subtype.
A1 Huertas, Ismael
A1 Jesús, Silvia
A1 Lojo, José Antonio
A1 García-Gómez, Francisco Javier
A1 Cáceres-Redondo, María Teresa
A1 Oropesa-Ruiz, Juan Manuel
A1 Carrillo, Fátima
A1 Vargas-Gonzalez, Laura
A1 Martín Rodríguez, Juan Francisco
A1 Gómez-Garre, Pilar
A1 García-Solís, David
A1 Mir, Pablo
AB Parkinson's disease (PD) patients who present with tremor and maintain a predominance of tremor have a better prognosis. Similarly, PD patients with high levels of uric acid (UA), a natural neuroprotectant, have also a better disease course. Our aim was to investigate whether PD motor subtypes differ in their levels of UA, and if these differences correlate with the degree of dopamine transporter (DAT) availability. We included 75 PD patients from whom we collected information about their motor symptoms, DAT imaging and UA concentration levels. Based on the predominance of their motor symptoms, patients were classified into postural instability and gait disorder (PIGD, n = 36), intermediate (I, n = 22), and tremor-dominant (TD, n = 17) subtypes. The levels of UA and striatal DAT were compared across subtypes and the correlation between these two measures was also explored. We found that PIGD patients had lower levels of UA (3.7 vs 4.5 vs 5.3 mg/dL; P
YR 2017
FD 2017-03-30
LK http://hdl.handle.net/10668/11023
UL http://hdl.handle.net/10668/11023
LA en
DS RISalud
RD Apr 6, 2025