RT Journal Article
T1 Coping with Stress During Aging: The Importance of a Resilient Brain.
A1 Sampedro-Piquero, P
A1 Alvarez-Suarez, P
A1 Begega, A
K1 Aging
K1 affective disorders
K1 brain
K1 healthy lifestyle
K1 resilience
K1 stress
AB Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging. In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response. Furthermore, using the EE paradigm, we analyse the resilient potential of this intervention and its neurobiological basis. In this case, we will focus on identifying the characteristics of a resilient brain (modifications in HPA structure and function, neurogenesis, specific neuron types, glia, neurotrophic factors, nitric oxide synthase or microRNAs, among others). The evidence suggests that a healthy lifestyle has a crucial role to promote a resilient brain during aging. Along with the behavioral changes described, a better regulation of HPA axis, enhanced levels of postmitotic type-3 cells or changes in GABAergic neurotransmission are some of the brain mechanisms involved in resilience. Future research should identify different biomarkers that increase the resistance to develop mood disorders and based on this knowledge, develop new potential therapeutic targets.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/11590
UL http://hdl.handle.net/10668/11590
LA en
DS RISalud
RD Apr 10, 2025