RT Conference Proceedings
T1 Higher red blood cell distribution width is associated with a worse virologic and clinical situation in HIV-infected patients.
A1 Puerta, S
A1 Gallego, M
A1 Palacios, S
A1 Ruiz, J
A1 Nuño, E
A1 Márquez, M
A1 Santos, J
K1 Infecciones por VIH
K1 Hipertensión
K1 VIH
K1 Eritrocitos
K1 Quimioterapia
K1 Carga viral
K1 Estudios Transversales
K1 Restricción Calórica
AB BackgroundA high level of red blood cell distribution width (RDW) is a novel prognostic marker that may reflect an underlying inflammatory state. It has recently shown that when increased, it is related to cardiovascular disease, mortality, and metabolic syndrome (MetS) in the general population.ObjectivesTo analyse the potential relation between high levels of RDW and cardiovascular risk (CVR) and MetS in HIVpatients.Patients and methodsObservational, cross-sectional study of a series of HIVoutpatients attended in our Hospital. Demographic, anthropometric, clinical, and fasting lab data were recorded in all cases. CVR at 10 years was evaluated by Framingham equation, and MetS diagnosed according to the National Cholesterol Education Program criteria. Statistic program: SPSS 17.0.Results666 patients were included, 79.3% were men, and mean age was 44.7 years. Mean CD4 count was 506 cells/ mm3 , 87.5% of the patients were on antiretroviral therapy, and 85.3% had undetectable HIV viral load. MeanRDW was 13.07% (range: 7.7-33.6%; 75th percentile 14,1%), with a prevalence of MetS of 15.7, 9.3, 18.8 and 16.6% first through fourth RDW quartile, and of patients with CVR >20% of 8.4, 4.0, 4.4 and 6.4%, respectively (p>0,05). The highest quartile of RDW (>14.1%) was associated with AIDS (OR 1.6, 95%CI 1.0-2.4; p 0.02), detectable HIV viral load (OR 1.5, 95%CI 1.01-2.4; p 0.04), and hypertension (OR 2.3, 95%CI 1.4-4.0; p 0.001).ConclusionsIn HIV-infected outpatients, higher RDW is related with detectable HIV viral load and with AIDS. Although it was associated with a traditional CVR factor as hypertension, we found no relation with MetS nor with higher CVR.
PB BioMed Central
YR 2010
FD 2010-11-08
LK http://hdl.handle.net/10668/958
UL http://hdl.handle.net/10668/958
LA en
NO Puerta,S; Gallego,M; Palacios,R; Ruiz,J; Nuño,E; Márquez,M; Santos,J. Higher red blood cell distribution width is associated with a worse virologic and clinical situation in HIV-infected patients. Journal of the International AIDS Society. 2010;13(Suppl 4):P69
DS RISalud
RD Apr 6, 2025