TY  - JOUR
AU  - Perazzoli, Gloria
AU  - Prados, Jose
AU  - Ortiz, Raul
AU  - Caba, Octavio
AU  - Cabeza, Laura
AU  - Berdasco, Maria
AU  - Gónzalez, Beatriz
AU  - Melguizo, Consolación
PY  - 2015
DO  - 10.1371/journal.pone.0140131
UR  - http://hdl.handle.net/10668/2596
T2  - PloS One
AB  - BACKGROUNDThe use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one of the main reasons why treatment fails. Although this resistance has frequently been linked to the expression...
LA  - en
PB  - Public Library of Science
KW  - Antineoplásicos alquilantes
KW  - Azacitidina
KW  - Línea celular tumoral
KW  - Metilación de ADN
KW  - Metilasas de modificación del ADN
KW  - Enzimas reparadoras del ADN
KW  - Tumor Suppressor Proteins
KW  - Dacarbazina
KW  - Resistencia a antineoplásicos
KW  - Epigénesis genética
KW  - Expresión génica
KW  - Regulación neoplásica de la expresión génica
KW  - Glicoproteínas
KW  - Guanina
KW  - Concentración 50 inhibidora
KW  - Glicoproteína P
KW  - Péptidos
KW  - Regiones promotoras genéticas
KW  - Proteínas supresoras de tumor
KW  - Antígenos CD
KW  - Regiones promotoras genéticas
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Antineoplastic Agents, Alkylating
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Aza Compounds::Azacitidine
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::DNA Methylation
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::DNA Restriction-Modification Enzymes::DNA Modification Methylases
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::DNA Repair Enzymes
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Triazenes::Dacarbazine
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma
KW  - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycoconjugates::Glycoproteins
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purinones::Hypoxanthines::Guanine
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Toxicity Tests::Inhibitory Concentration 50
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::ATP-Binding Cassette Transporters::P-Glycoproteins
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Tumor Suppressor Proteins
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Antigens, Differentiation::Antigens, CD
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequence::Regulatory Sequences, Nucleic Acid::Promoter Regions, Genetic
TI  - Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression.
TY  - research article
ER  -