TY  - JOUR
AU  - Benitez-Guijarro, Maria
AU  - Lopez-Ruiz, Cesar
AU  - Tarnauskaitė, Žygimantė
AU  - Murina, Olga
AU  - Mian Mohammad, Mahwish
AU  - Williams, Thomas C
AU  - Fluteau, Adeline
AU  - Sanchez, Laura
AU  - Vilar-Astasio, Raquel
AU  - Garcia-Canadas, Marta
AU  - Cano, David
AU  - Kempen, Marie-Jeanne Hc
AU  - Sanchez-Pozo, Antonio
AU  - Heras, Sara R
AU  - Jackson, Andrew P
AU  - Reijns, Martin Am
AU  - Garcia-Perez, Jose L
PY  - 2018
DO  - 10.15252/embj.201798506
UR  - http://hdl.handle.net/10668/12660
T2  - The EMBO journal
AB  - Long INterspersed Element class 1 (LINE-1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition-competent LINE-1s, whose activity is influenced by the combined action of...
LA  - en
KW  - Aicardi‐Goutières Syndrome
KW  - LINE‐1 retrotransposition
KW  - RNA:DNA hybrids
KW  - RNase H2
KW  - Autoimmune Diseases of the Nervous System
KW  - Cell Line, Tumor
KW  - Gene Knockout Techniques
KW  - HCT116 Cells
KW  - HeLa Cells
KW  - Humans
KW  - Long Interspersed Nucleotide Elements
KW  - Nervous System Malformations
KW  - Reverse Transcription
KW  - Ribonuclease H
TI  - RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition.
TY  - research article
VL  - 37
ER  -