RT Journal Article
T1 Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
A1 de-Rojas, Itziar
A1 Moreno-Grau, Sonia
A1 Tesi, Niccolo
A1 Grenier-Boley, Benjamin
A1 Andrade, Victor
A1 Jansen, Iris E
A1 Pedersen, Nancy L
A1 Stringa, Najada
A1 Zettergren, Anna
A1 Hernández, Isabel
A1 Montrreal, Laura
A1 Antúnez, Carmen
A1 Antonell, Anna
A1 Tankard, Rick M
A1 Bis, Joshua C
A1 Sims, Rebecca
A1 Bellenguez, Céline
A1 Quintela, Inés
A1 González-Perez, Antonio
A1 Calero, Miguel
A1 Franco-Macias, Emilio
A1 Macias, Juan
A1 Blesa, Rafael
A1 Cervera-Carles, Laura
A1 Menendez-Gonzalez, Manuel
A1 Frank-Garcia, Ana
A1 Royo, Jose Luis
A1 Moreno, Fermin
A1 Huerto-Vilas, Raquel
A1 Baquero, Miquel
A1 Diez-Fairen, Monica
A1 Lage, Carmen
A1 Garcia-Madrona, Sebastian
A1 Garcia-Gonzalez, Pablo
A1 Alarcon-Martin, Emilio
A1 Valero, Sergi
A1 Sotolongo-Grau, Oscar
A1 Ullgren, Abbe
A1 Naj, Adam C
A1 Lemstra, Afina W
A1 Benaque, Alba
A1 Perez-Cordon, Alba
A1 Benussi, Alberto
A1 Rabano, Alberto
A1 Padovani, Alessandro
A1 Squassina, Alessio
A1 de-Mendonça, Alexandre
A1 Arias-Pastor, Alfonso
A1 Kok, Almar A L
A1 Meggy, Alun
A1 Pastor, Ana Belen
A1 Espinosa, Ana
A1 Corma-Gomez, Anaïs
A1 Martin-Montes, Angel
A1 Sanabria, Angela
A1 DeStefano, Anita L
A1 Schneider, Anja
A1 Haapasalo, Annakaisa
A1 Kinhult-Ståhlbom, Anne
A1 Tybjærg-Hansen, Anne
A1 Hartmann, Annette M
A1 Spottke, Annika
A1 Corbaton-Anchuelo, Arturo
A1 Rongve, Arvid
A1 Borroni, Barbara
A1 Arosio, Beatrice
A1 Nacmias, Benedetta
A1 Nordestgaard, Børge G
A1 Kunkle, Brian W
A1 Charbonnier, Camille
A1 Abdelnour, Carla
A1 Masullo, Carlo
A1 Martinez-Rodriguez, Carmen
A1 Muñoz-Fernandez, Carmen
A1 Dufouil, Carole
A1 Graff, Caroline
A1 Ferreira, Catarina B
A1 Chillotti, Caterina
A1 Reynolds, Chandra A
A1 Fenoglio, Chiara
A1 Van-Broeckhoven, Christine
A1 Clark, Christopher
A1 Pisanu, Claudia
A1 Satizabal, Claudia L
A1 Holmes, Clive
A1 Buiza-Rueda, Dolores
A1 Aarsland, Dag
A1 Rujescu, Dan
A1 Alcolea, Daniel
A1 Galimberti, Daniela
A1 Wallon, David
A1 Seripa, Davide
A1 Grünblatt, Edna
A1 Dardiotis, Efthimios
A1 Düzel, Emrah
A1 Scarpini, Elio
A1 Conti, Elisa
A1 Rubino, Elisa
A1 Gelpi, Ellen
A1 Rodriguez-Rodriguez, Eloy
A1 Duron, Emmanuelle
A1 Boerwinkle, Eric
A1 Ferri, Evelyn
A1 Tagliavini, Fabrizio
A1 Küçükali, Fahri
A1 Pasquier, Florence
A1 Sanchez-Garcia, Florentino
A1 Mangialasche, Francesca
A1 Jessen, Frank
A1 Nicolas, Gaël
A1 Selbæk, Geir
A1 Ortega, Gemma
A1 Chêne, Geneviève
A1 Hadjigeorgiou, Georgios
A1 Rossi, Giacomina
A1 Spalletta, Gianfranco
A1 Giaccone, Giorgio
A1 Grande, Giulia
A1 Binetti, Giuliano
A1 Papenberg, Goran
A1 Hampel, Harald
A1 Bailly, Henri
A1 Zetterberg, Henrik
A1 Soininen, Hilkka
A1 Karlsson, Ida K
A1 Alvarez, Ignacio
A1 Appollonio, Ildebrando
A1 Giegling, Ina
A1 Skoog, Ingmar
A1 Saltvedt, Ingvild
A1 Rainero, Innocenzo
A1 Rosas-Allende, Irene
A1 Hort, Jakub
A1 Diehl-Schmid, Janine
A1 Van-Dongen, Jasper
A1 Vidal, Jean-Sebastien
A1 Lehtisalo, Jenni
A1 Wiltfang, Jens
A1 Thomassen, Jesper Qvist
A1 Kornhuber, Johannes
A1 Haines, Jonathan L
A1 Vogelgsang, Jonathan
A1 Pineda, Juan A
A1 Fortea, Juan
A1 Popp, Julius
A1 Deckert, Jürgen
A1 Buerger, Katharina
A1 Morgan, Kevin
A1 Fließbach, Klaus
A1 Sleegers, Kristel
A1 Molina-Porcel, Laura
A1 Kilander, Lena
A1 Weinhold, Leonie
A1 Farrer, Lindsay A
A1 Wang, Li-San
A1 Kleineidam, Luca
A1 Farotti, Lucia
A1 Parnetti, Lucilla
A1 Tremolizzo, Lucio
A1 Hausner, Lucrezia
A1 Benussi, Luisa
A1 Froelich, Lutz
A1 Ikram, M Arfan
A1 Deniz-Naranjo, M Candida
A1 Tsolaki, Magda
A1 Rosende-Roca, Maitee
A1 Löwenmark, Malin
A1 Hulsman, Marc
A1 Spallazzi, Marco
A1 Pericak-Vance, Margaret A
A1 Esiri, Margaret
A1 Bernal-Sanchez-Arjona, Maria
A1 Dalmasso, Maria Carolina
A1 Martinez-Larrad, Maria Teresa
A1 Arcaro, Marina
A1 Nöthen, Markus M
A1 Fernandez-Fuertes, Marta
A1 Dichgans, Martin
A1 Ingelsson, Martin
A1 Herrmann, Martin J
A1 Scherer, Martin
A1 Vyhnalek, Martin
A1 Kosmidis, Mary H
A1 Yannakoulia, Mary
A1 Schmid, Matthias
A1 Ewers, Michael
A1 Heneka, Michael T
A1 Wagner, Michael
A1 Scamosci, Michela
A1 Kivipelto, Miia
A1 Hiltunen, Mikko
A1 Zulaica, Miren
A1 Alegret, Montserrat
A1 Fornage, Myriam
A1 Roberto, Natalia
A1 van-Schoor, Natasja M
A1 Seidu, Nazib M
A1 Banaj, Nerisa
A1 Armstrong, Nicola J
A1 Scarmeas, Nikolaos
A1 Scherbaum, Norbert
A1 Goldhardt, Oliver
A1 Hanon, Oliver
A1 Peters, Oliver
A1 Skrobot, Olivia Anna
A1 Quenez, Olivier
A1 Lerch, Ondrej
A1 Bossu, Paola
A1 Caffarra, Paolo
A1 Dionigi-Rossi, Paolo
A1 Sakka, Paraskevi
A1 Mecocci, Patrizia
A1 Hoffmann, Per
A1 Holmans, Peter A
A1 Fischer, Peter
A1 Riederer, Peter
A1 Yang, Qiong
A1 Marshall, Rachel
A1 Kalaria, Rajesh N
A1 Mayeux, Richard
A1 Vandenberghe, Rik
A1 Cecchetti, Roberta
A1 Ghidoni, Roberta
A1 Frikke-Schmidt, Ruth
A1 Sorbi, Sandro
A1 Hägg, Sara
A1 Engelborghs, Sebastiaan
A1 Helisalmi, Seppo
A1 Botne-Sando, Sigrid
A1 Kern, Silke
A1 Archetti, Silvana
A1 Boschi, Silvia
A1 Fostinelli, Silvia
A1 Gil, Silvia
A1 Mendoza, Silvia
A1 Mead, Simon
A1 Ciccone, Simona
A1 Djurovic, Srdjan
A1 Heilmann-Heimbach, Stefanie
A1 Riedel-Heller, Steffi
A1 Kuulasmaa, Teemu
A1 Del Ser, Teodoro
A1 Lebouvier, Thibaud
A1 Polak, Thomas
A1 Ngandu, Tiia
A1 Grimmer, Timo
A1 Bessi, Valentina
A1 Escott-Price, Valentina
A1 Giedraitis, Vilmantas
A1 Deramecourt, Vincent
A1 Maier, Wolfgang
A1 Jian, Xueqiu
A1 Pijnenburg, Yolande A L
A1 Kehoe, Patrick Gavin
A1 Garcia-Ribas, Guillermo
A1 Sanchez-Juan, Pascual
A1 Pastor, Pau
A1 Perez-Tur, Jordi
A1 Piñol-Ripoll, Gerard
A1 Lopez-de-Munain, Adolfo
A1 Garcia-Alberca, Jose Maria
A1 Bullido, Maria J
A1 Alvarez, Victoria
A1 Lleo, Alberto
A1 Real, Luis M
A1 Mir, Pablo
A1 Medina, Miguel
A1 Scheltens, Philip
A1 Holstege, Henne
A1 Marquie, Marta
A1 Saez, Maria Eugenia
A1 Carracedo, Angel
A1 Amouyel, Philippe
A1 Schellenberg, Gerard D
A1 Williams, Julie
A1 Seshadri, Sudha
A1 van-Duijn, Cornelia M
A1 Mather, Karen A
A1 Sanchez-Valle, Raquel
A1 Serrano-Rios, Manuel
A1 Orellana, Adelina
A1 Tarraga, Lluis
A1 Blennow, Kaj
A1 Huisman, Martijn
A1 Andreassen, Ole A
A1 Posthuma, Danielle
A1 Clarimon, Jordi
A1 Boada, Merce
A1 van-der-Flier, Wiesje M
A1 Ramirez, Alfredo
A1 Lambert, Jean-Charles
A1 van-der-Lee, Sven J
A1 Ruiz, Agustin
K1 Age of Onset
K1 Alzheimer Disease
K1 Apolipoproteins E
K1 Datasets as Topic
K1 Genetic Predisposition to Disease
K1 Genome-Wide Association Study
K1 Male
K1 Polymorphism, Single Nucleotide
K1 Risk Factors
AB Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.
PB Nature Publishing Group
YR 2021
FD 2021-06-07
LK https://hdl.handle.net/10668/27256
UL https://hdl.handle.net/10668/27256
LA en
NO de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 2021 Jun 7;12(1):3417.
DS RISalud
RD Apr 5, 2025