RT Journal Article
T1 Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii.
A1 García-Quintanilla, Meritxell
A1 Caro-Vega, José M
A1 Pulido, Marina R
A1 Moreno-Martínez, Patricia
A1 Pachón, Jerónimo
A1 McConnell, Michael J
AB LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of PF-5081090 at 32 mg/liter increased susceptibility to rifampin, vancomycin, azithromycin, imipenem, and amikacin but had no effect on susceptibility to ciprofloxacin and tigecycline. Potentiating existing antibiotics with LpxC inhibitors may represent an alternative treatment strategy for multidrug-resistant A. baumannii.
YR 2016
FD 2016-07-22
LK http://hdl.handle.net/10668/10157
UL http://hdl.handle.net/10668/10157
LA en
DS RISalud
RD Apr 18, 2025