RT Journal Article
T1 Spanish consensus guidelines on prophylaxis with bypassing agents for surgery in patients with haemophilia and inhibitors.
A1 Mingot-Castellano, Maria Eva
A1 Alvarez-Roman, Maria Teresa
A1 Lopez-Fernandez, Maria Fernanda
A1 Altisent-Roca, Carmen
A1 Canaro-Hirnyk, Mariana Isabel
A1 Jimenez-Yuste, Victor
A1 Cid-Haro, Ana Rosa
A1 Perez-Garrido, Rosario
A1 Sedano-Balbas, Carmen
K1 Consensus
K1 Inhibitors
K1 Prophylaxis
K1 Surgery haemophilia
K1 Factor VIIa
K1 Hemophilia A
K1 Hemorrhage
AB Patients with severe haemophilia and inhibitors against factor VIII who require surgery need a prophylactic approach to prevent bleeding complications. Scientific evidence to decide the best prophylactic treatment is very limited and mainly based on retrospective or case series. To develop evidence- and expert opinion-based guidelines for prophylactic therapy for patients with haemophilia and inhibitors undergoing surgery. A panel of nine Spanish haematologists undertook a systematic review of the literature and selected publications providing relevant information regarding the prophylactic management of patients with haemophilia and inhibitors undergoing dental extraction, minor surgery or major surgery. Although evidence is very limited, the panel considers that it seems advisable that prophylaxis should be given in most cases with a bypassing agent (aPCC or rFVIIa) and should start immediately before minor or major surgery. Patients should be closely monitored to enable dose/product modification as needed. It is necessary to communicate clinical experience in a detailed way in order to ensure optimal schemes of prophylaxis for patients with haemophilia and inhibitors. Development of objective outcomes to evaluate efficacy is crucial.
PB John Wiley and Sons
YR 2016
FD 2016-04-08
LK http://hdl.handle.net/10668/9687
UL http://hdl.handle.net/10668/9687
LA en
NO Mingot-Castellano ME, Álvarez-Román MT, López-Fernández MF, Altisent-Roca C, Canaro-Hirnyk MI, Jiménez-Yuste V, et al. Spanish consensus guidelines on prophylaxis with bypassing agents for surgery in patients with haemophilia and inhibitors. Eur J Haematol. 2016 May;96(5):461-74
DS RISalud
RD Oct 13, 2025