RT Journal Article T1 Spanish consensus guidelines on prophylaxis with bypassing agents for surgery in patients with haemophilia and inhibitors. A1 Mingot-Castellano, María Eva A1 Álvarez-Román, María Teresa A1 López-Fernández, María Fernanda A1 Altisent-Roca, Carmen A1 Canaro-Hirnyk, Mariana Isabel A1 Jiménez-Yuste, Víctor A1 Cid-Haro, Ana Rosa A1 Pérez-Garrido, Rosario A1 Sedano-Balbas, Carmen K1 consensus K1 inhibitors K1 prophylaxis K1 surgery haemophilia AB Patients with severe haemophilia and inhibitors against factor VIII who require surgery need a prophylactic approach to prevent bleeding complications. Scientific evidence to decide the best prophylactic treatment is very limited and mainly based on retrospective or case series. To develop evidence- and expert opinion-based guidelines for prophylactic therapy for patients with haemophilia and inhibitors undergoing surgery. A panel of nine Spanish haematologists undertook a systematic review of the literature and selected publications providing relevant information regarding the prophylactic management of patients with haemophilia and inhibitors undergoing dental extraction, minor surgery or major surgery. Although evidence is very limited, the panel considers that it seems advisable that prophylaxis should be given in most cases with a bypassing agent (aPCC or rFVIIa) and should start immediately before minor or major surgery. Patients should be closely monitored to enable dose/product modification as needed. It is necessary to communicate clinical experience in a detailed way in order to ensure optimal schemes of prophylaxis for patients with haemophilia and inhibitors. Development of objective outcomes to evaluate efficacy is crucial. YR 2016 FD 2016-02-04 LK http://hdl.handle.net/10668/9687 UL http://hdl.handle.net/10668/9687 LA en DS RISalud RD Apr 11, 2025