%0 Journal Article
%A Nogueras-Morillas, Paloma
%A Blasco-Morente, Gonzalo
%A Espadafor-López, Beatriz
%A Aneiros-Fernández, José
%A Tercedor-Sánchez, Jesús
%T Keratotic Nodule on The Heel: A Quiz.
%D 2016
%@ 0001-5555
%U http://hdl.handle.net/10668/2193
%X A 51-year-old man, with a medical history of medullary thyroid carcinoma excised under thyroxine treatment presented with a painful enlarging lesion on his right heel since one year. A 3-cm diameter, greyish, infiltrated nodule with spicules was seen on physical examination (Fig. 1a). A 5-mm surgical excision was made and a total skin graft was used for reconstruction. Histopathology of the total resected tumour revealed pseudoepitheliomatous hyperplasic epidermis and a proliferation located between rete ridges, dermis and superficial hypodermis (Fig. 1b). The proliferation was composed of nets and cordons of cells with granular and abundant PAS-positive cytoplasm. Immunostains showed cytoplasmic positivity for s100 and inhibin (Fig. 1c). Three years later the patient is asymptomatic.
%K Talón
%K Inhibinas
%K Neoplasias
%K Proteínas de transporte de noradrenalina a través de la membrana plasmática
%K Trasplante de piel
%K Tejido subcutáneo
%K Tiroxina
%K Tumor de células granulares
%~