RT Journal Article
T1 Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine
A1 Pendón-Ruiz de Mier, María Victoria
A1 Vergara, Noemí
A1 Rodelo-Haad, Cristian
A1 López-Zamorano, María Dolores
A1 Membrives-González, Cristina
A1 López-Baltanás, Rodrigo
A1 Muñoz-Castañeda, Juan Rafael
A1 Caravaca, Francisco
A1 Martín-Malo, Alejandro
A1 Felsenfeld, Arnold J.
A1 De la Torre, Eugenio J.
A1 Soriano, Sagrario
A1 Santamaría, Rafael
A1 Rodríguez, Mariano
K1 Phosphaturia
K1 Phosphate intake
K1 FGF23
K1 PTH
K1 CKD
K1 Hipofosfatemia familiar
K1 Factor de crecimiento fibroblástico 23
K1 Hormona paratiroidea
K1 Insuficiencia renal crónica
AB In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit the intake of P contained in proteins. Urinary excretion of P should reflect intestinal absorption of P(inorganic plus protein-derived). The aim of the present study is to determine whether the ratio of urinary P to urinary urea nitrogen (P/UUN ratio) helps identify patients with a high intake of inorganic P.A cross-sectional study was performed in 71 patients affected by metabolic syndrome with CKD (stages 2-3) with normal serum P concentration. A 3-day dietary survey was performed to estimate the average daily amount and the source of P ingested. The daily intake ofPwas1086.5 ± 361.3mg/day; 64% contained in animal proteins, 22% in vegetable proteins, and 14% as inorganic P. The total amount of P ingested did not correlate with daily phosphaturia, but it did correlate with the P/UUN ratio (p < 0.018). Patients with the highest tertile of the P/UUN ratio >71.1 mg/g presented more abundant inorganic P intake (p < 0.038).The P/UUN ratio is suggested to be a marker of inorganic P intake. This finding might be useful in clinical practices to identify the source of dietary P and to make personalized dietary recommendations directed to reduce inorganic P intake.
PB MDPI
YR 2021
FD 2021-01-20
LK http://hdl.handle.net/10668/4014
UL http://hdl.handle.net/10668/4014
LA en
NO Pendón-Ruiz de Mier MV, Vergara N, Rodelo-Haad C, López-Zamorano MD, Membrives-González C, López-Baltanás R, et al. Assessment of Inorganic Phosphate Intake by the Measurement of the Phosphate/Urea Nitrogen Ratio in Urine. Nutrients. 2021 Jan 20;13(2):292
DS RISalud
RD Apr 7, 2025