RT Journal Article
T1 Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus.
A1 Rua-Figueroa, Iñigo
A1 Lopez-Longo, Javier
A1 Galindo-Izquierdo, Maria
A1 Calvo-Alen, Jaime
A1 Del-Campo, Victor
A1 Olive-Marques, Alejandro
A1 Perez-Vicente, Sabina
A1 Fernandez-Nebro, Antonio
A1 Andres, Mariano
A1 Erausquin, Celia
A1 Tomero, Eva
A1 Horcada, Loreto
A1 Uriarte, Esther
A1 Freire, Mercedes
A1 Montilla, Carlos
A1 Sanchez-Atrio, Ana
A1 Santos, Gregorio
A1 Boteanu, Alina
A1 Diez-Alvarez, Elvira
A1 Narvaez, Javier
A1 Martinez-Taboada, Victor
A1 Silva-Fernandez, Lucia
A1 Ruiz-Lucea, Esther
A1 Andreu, Jose Luis
A1 Hernandez-Beriain, Jose Angel
A1 Gantes, Marian
A1 Hernandez-Cruz, Blanca
A1 Perez-Venegas, Jose
A1 Pecondon-Español, Angela
A1 Marras, Carlos
A1 Ibañez-Barcelo, Monica
A1 Bonilla, Gema
A1 Torrente, Vicente
A1 Castellvi, Ivan
A1 Alegre, Juan Jose
A1 Calvet, Joan
A1 Marenco, Jose Luis
A1 Raya, Enrique
A1 Vazquez, Tomás
A1 Quevedo, Victor
A1 Muñoz-Fernandez, Santiago
A1 Rodriguez-Gomez, Manuel
A1 Ibañez, Jesus
A1 Pego-Reigosa, Jose M
K1 Antimalarials
K1 Infection
K1 Systemic lupus erythematosus
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
K1 Área de Gestión Sanitaria Sur de Sevilla
AB To estimate the incidence of severe infection and investigate the associated factors and clinical impact in a large systemic lupus erythematosus (SLE) retrospective cohort. All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria were retrospectively investigated for severe infections. Patients with and without infections were compared in terms of SLE severity, damage, comorbidities, and demographic characteristics. A multivariable Cox regression model was built to calculate hazard ratios (HRs) for the first infection. A total of 3658 SLE patients were included: 90% female, median age 32.9 years (DQ 9.7), and mean follow-up (months) 120.2 (±87.6). A total of 705 (19.3%) patients suffered ≥1 severe infection. Total severe infections recorded in these patients numbered 1227. The incidence rate was 29.2 (95% CI: 27.6-30.9) infections per 1000 patient years. Time from first infection to second infection was significantly shorter than time from diagnosis to first infection (p  Severe infection constitutes a predictor of poor prognosis in SLE patients, is more common in Latin-Americans and is associated with age, previous infection, and smoking. Antimalarials exerted a protective effect.
PB Elsevier
YR 2017
FD 2017-07-26
LK http://hdl.handle.net/10668/10932
UL http://hdl.handle.net/10668/10932
LA en
NO Rúa-Figueroa Í, López-Longo J, Galindo-Izquierdo M, Calvo-Alén J, Del Campo V, Olivé-Marqués A, et al. Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus. Semin Arthritis Rheum. 2017 Aug;47(1):38-45
DS RISalud
RD Apr 12, 2025