%0 Journal Article
%A Rua-Figueroa, Iñigo
%A Lopez-Longo, Javier
%A Galindo-Izquierdo, Maria
%A Calvo-Alen, Jaime
%A Del-Campo, Victor
%A Olive-Marques, Alejandro
%A Perez-Vicente, Sabina
%A Fernandez-Nebro, Antonio
%A Andres, Mariano
%A Erausquin, Celia
%A Tomero, Eva
%A Horcada, Loreto
%A Uriarte, Esther
%A Freire, Mercedes
%A Montilla, Carlos
%A Sanchez-Atrio, Ana
%A Santos, Gregorio
%A Boteanu, Alina
%A Diez-Alvarez, Elvira
%A Narvaez, Javier
%A Martinez-Taboada, Victor
%A Silva-Fernandez, Lucia
%A Ruiz-Lucea, Esther
%A Andreu, Jose Luis
%A Hernandez-Beriain, Jose Angel
%A Gantes, Marian
%A Hernandez-Cruz, Blanca
%A Perez-Venegas, Jose
%A Pecondon-Español, Angela
%A Marras, Carlos
%A Ibañez-Barcelo, Monica
%A Bonilla, Gema
%A Torrente, Vicente
%A Castellvi, Ivan
%A Alegre, Juan Jose
%A Calvet, Joan
%A Marenco, Jose Luis
%A Raya, Enrique
%A Vazquez, Tomás
%A Quevedo, Victor
%A Muñoz-Fernandez, Santiago
%A Rodriguez-Gomez, Manuel
%A Ibañez, Jesus
%A Pego-Reigosa, Jose M
%T Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus.
%D 2017
%U http://hdl.handle.net/10668/10932
%X To estimate the incidence of severe infection and investigate the associated factors and clinical impact in a large systemic lupus erythematosus (SLE) retrospective cohort. All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet ≥4 ACR-97 SLE criteria were retrospectively investigated for severe infections. Patients with and without infections were compared in terms of SLE severity, damage, comorbidities, and demographic characteristics. A multivariable Cox regression model was built to calculate hazard ratios (HRs) for the first infection. A total of 3658 SLE patients were included: 90% female, median age 32.9 years (DQ 9.7), and mean follow-up (months) 120.2 (±87.6). A total of 705 (19.3%) patients suffered ≥1 severe infection. Total severe infections recorded in these patients numbered 1227. The incidence rate was 29.2 (95% CI: 27.6-30.9) infections per 1000 patient years. Time from first infection to second infection was significantly shorter than time from diagnosis to first infection (p  Severe infection constitutes a predictor of poor prognosis in SLE patients, is more common in Latin-Americans and is associated with age, previous infection, and smoking. Antimalarials exerted a protective effect.
%K Antimalarials
%K Infection
%K Systemic lupus erythematosus
%K Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
%K Área de Gestión Sanitaria Sur de Sevilla
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