RT Journal Article
T1 The role of bronchoscopy in patients with SARS-CoV-2 pneumonia
A1 Arenas-De Larriva, Marisol
A1 Martín-DeLeon, Roberto
A1 Urrutia Royo, Blanca
A1 Fernández-Navamuel, Iker
A1 Gimenez Velando, Andrés
A1 Nuñez García, Laura
A1 Centeno Clemente, Carmen
A1 Andreo García, Felipe
A1 Rafecas Codern, Albert
A1 Fernández-Arias, Carmen
A1 Pajares Ruiz, Virginia
A1 Torrego Fernández, Alfons
A1 Rajas, Olga
A1 Iturricastillo, Gorane
A1 Garcia Lujan, Ricardo
A1 Comeche Casanova, Lorena
A1 Sánchez-Font, Albert
A1 Aguilar-Colindres, Ricardo
A1 Larrosa-Barrero, Roberto
A1 García García, Ruth
A1 Cordovilla, Rosa
A1 Núñez-Ares, Ana
A1 Briones-Gómez, Andrés
A1 Cases Viedma, Enrique
A1 Franco, José
A1 Cosano Povedano, Javier
A1 Rodríguez-Perálvarez, Manuel Luis
A1 Cebrian Gallardo, Jose Joaquin
A1 Nuñez Delgado, Manuel
A1 Pavón-Masa, María
A1 Valdivia Salas, Maria Del Mar
A1 Flandes, Javier
K1 Bronchoscopy
K1 SARS-CoV-2
K1 Pneumonia
K1 Mucus
K1 COVID-19
K1 Broncoscopía
K1 Neumonía
K1 Moco
AB Background The role of bronchoscopy in coronavirus disease 2019 (COVID-19) is a matter of debate. Patients and methods This observational multicentre study aimed to analyse the prognostic impact of bronchoscopic findings in a consecutive cohort of patients with suspected or confirmed COVID-19. Patients were enrolled at 17 hospitals from February to June 2020. Predictors of in-hospital mortality were assessed by multivariate logistic regression. Results A total of 1027 bronchoscopies were performed in 515 patients (age 61.5±11.2 years; 73% men), stratified into a clinical suspicion cohort (n=30) and a COVID-19 confirmed cohort (n=485). In the clinical suspicion cohort, the diagnostic yield was 36.7%. In the COVID-19 confirmed cohort, bronchoscopies were predominantly performed in the intensive care unit (n=961; 96.4%) and major indications were: difficult mechanical ventilation (43.7%), mucus plugs (39%) and persistence of radiological infiltrates (23.4%). 147 bronchoscopies were performed to rule out superinfection, and diagnostic yield was 42.9%. There were abnormalities in 91.6% of bronchoscopies, the most frequent being mucus secretions (82.4%), haematic secretions (17.7%), mucus plugs (17.6%), and diffuse mucosal hyperaemia (11.4%). The independent predictors of in-hospital mortality were: older age (OR 1.06; p<0.001), mucus plugs as indication for bronchoscopy (OR 1.60; p=0.041), absence of mucosal hyperaemia (OR 0.49; p=0.041) and the presence of haematic secretions (OR 1.79; p=0.032). Conclusion Bronchoscopy may be indicated in carefully selected patients with COVID-19 to rule outsuperinfection and solve complications related to mechanical ventilation. The presence of haematic secretions in the distal bronchial tract may be considered a poor prognostic feature in COVID-19.
PB European Respiratory Society
YR 2021
FD 2021
LK http://hdl.handle.net/10668/3821
UL http://hdl.handle.net/10668/3821
LA en
NO Arenas-De Larriva M, Martín-DeLeon R, Urrutia Royo B, Fernández-Navamuel I, Gimenez Velando A, Nuñez García L, et al. The role of bronchoscopy in patients with SARS-CoV-2 pneumonia. ERJ Open Res. 2021 Jul 12;7(3):00165-2021
DS RISalud
RD Apr 17, 2025