TY  - JOUR
AU  - Alors-Perez, Emilia
AU  - Blázquez-Encinas, Ricardo
AU  - Alcalá, Sonia
AU  - Viyuela-García, Cristina
AU  - Pedraza-Arevalo, Sergio
AU  - Herrero-Aguayo, Vicente
AU  - Jiménez-Vacas, Juan M.
AU  - Mafficini, Andrea
AU  - Sánchez-Frías, Marina E.
AU  - Cano, María T.
AU  - Abollo-Jiménez, Fernando
AU  - Marín-Sanz, Juan A.
AU  - Cabezas-Sainz, Pablo
AU  - Lawlor, Rita T.
AU  - Luchini, Claudio
AU  - Sánchez, Laura
AU  - Sánchez-Hidalgo, Juan M.
AU  - Ventura, Sebastián
AU  - Martin-Hijano, Laura
AU  - Gahete, Manuel D.
AU  - Scarpa, Aldo
AU  - Arjona-Sánchez, Álvaro
AU  - Ibáñez-Costa, Alejandro
AU  - Sainz, Bruno
AU  - Luque, Raúl M.
AU  - Castaño, Justo P.
PY  - 2021
DO  - 10.1186/s13046-021-02153-9
UR  - http://hdl.handle.net/10668/4513
T2  - Journal of Experimental & Clinical Cancer Research
AB  - BackgroundPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallmark and an attractive...
LA  - en
PB  - BioMed Central, Springer Nature
KW  - Pancreatic cancer
KW  - Splicing-spliceosome
KW  - SF3B1
KW  - Pladienolide-B
KW  - Cancer stem cells
KW  - Carcinoma, pancreatic ductal
KW  - Cell proliferation
KW  - Apoptosis
KW  - Cell line
KW  - Neoplasias pancreáticas
KW  - Empalmosomas
KW  - Células madre neoplásicas
KW  - Carcinoma ductal pancreático
KW  - Proliferación celular
KW  - Línea celular
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Phosphoproteins
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Fishes::Cypriniformes::Cyprinidae::Zebrafish
KW  - Medical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::Pancreatic Neoplasms::Carcinoma, Pancreatic Ductal
KW  - Medical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::Pancreatic Neoplasms
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics
TI  - Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
TY  - research article
ER  -