RT Journal Article
T1 Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis.
A1 Ferraz-Amaro, Iván
A1 Rueda-Gotor, Javier
A1 Genre, Fernanda
A1 Corrales, Alfonso
A1 Blanco, Ricardo
A1 Portilla, Virginia
A1 González Mazón, Iñigo
A1 Llorca, Javier
A1 Expósito, Rosa
A1 Vicente, Esther F
A1 Quevedo-Abeledo, Juan Carlos
A1 Rodríguez-Lozano, Carlos
A1 Ortega-Castro, Rafaela
A1 Ladehesa-Pineda, María Lourdes
A1 Fernández-Carballido, Cristina
A1 Martínez-Vidal, M Paz
A1 Castro-Corredor, David
A1 Anino-Fernández, Joaquín
A1 García Vivar, María Luz
A1 Galíndez-Agirregoikoa, Eva
A1 Peiteado, Diana
A1 Plasencia-Rodríguez, Chamaida
A1 Montes Perez, Esther
A1 Fernández Díaz, Carlos
A1 Castañeda, Santos
A1 González-Gay, Miguel Ángel
K1 axial spondyloarthritis
K1 cardiovascular risk factors
K1 disease activity
AB Axial spondyloarthritis (axSpA) patients are known to have a higher prevalence of several comorbidities, including, among others, an increased risk of atherosclerosis, hypertension, dyslipidemia, and diabetes. The purpose of the present study was to determine whether the sum of traditional cardiovascular (CV) risk factors is related to disease characteristics, such as disease activity, in patients with axSpA. A cross-sectional study that encompassed 804 patients with axSpA was conducted. Patients were assessed for the presence of five traditional CV risk factors (diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking status), and disease activity measurements. A multivariable regression analysis was performed to evaluate whether the number of classic CV risk factors was independently associated with specific features of the disease, to include disease activity. A multivariable analysis showed that Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP) activity score was significantly higher in patients with 1 [beta coefficient 0.3 (95% confidence interval (CI) 0.1-0.5), p = 0.001] and ⩾2 [beta coefficient 0.5 (95% CI 0.3-0.7), p = 0.000] CV risk factors compared with those without CV risk factors. Similarly, patients with 1 [OR 2.00 (95%CI 0.99-4.02), p = 0.053] and ⩾2 [OR 3.39 (95%CI 1.82-6.31), p = 0.000] CV risk factors had a higher odds ratio for the presence of high disease activity compared with the zero CV category. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) activity score was significantly associated with the number of CV risk factors, being higher in patients with more CV risk factors. These relationships showed a CV risk factor-dependent effect being beta coefficients and ORs higher for the effect of ⩾2 over 1 CV risk factor. Among patients with axSpA, as the number of traditional CV risk factors increased, disease activity similarly increases in an independent manner.
SN 1759-720X
YR 2021
FD 2021-07-28
LK http://hdl.handle.net/10668/18357
UL http://hdl.handle.net/10668/18357
LA en
DS RISalud
RD Apr 6, 2025