RT Journal Article
T1 A prospective evaluation of plasma polyphenol levels and colon cancer risk.
A1 Murphy, Neil
A1 Achaintre, David
A1 Zamora-Ros, Raul
A1 Jenab, Mazda
A1 Boutron-Ruault, Marie-Christine
A1 Carbonnel, Franck
A1 Savoye, Isabelle
A1 Kaaks, Rudolf
A1 Kühn, Tilman
A1 Boeing, Heiner
A1 Aleksandrova, Krasimira
A1 Tjønneland, Anne
A1 Kyrø, Cecilie
A1 Overvad, Kim
A1 Quirós, J Ramón
A1 Sanchez-Perez, Maria-Jose
A1 Altzibar, Jone M
A1 María Huerta, José
A1 Barricarte, Aurelio
A1 Khaw, Kay-Tee
A1 Bradbury, Kathryn E
A1 Perez-Cornago, Aurora
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Peppa, Eleni
A1 Palli, Domenico
A1 Grioni, Sara
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Panico, Salvatore
A1 Bueno-de-Mesquita, H B As
A1 Peeters, Petra H
A1 Rutegård, Martin
A1 Johansson, Ingegerd
A1 Freisling, Heinz
A1 Noh, Hwayoung
A1 Cross, Amanda J
A1 Vineis, Paolo
A1 Tsilidis, Kostas
A1 Gunter, Marc J
A1 Scalbert, Augustin
K1 EPIC
K1 biomarkers
K1 colon cancer
K1 nested case-control study
K1 polyphenols
AB Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue  = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue  = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend  = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend  
YR 2018
FD 2018-06-11
LK http://hdl.handle.net/10668/12396
UL http://hdl.handle.net/10668/12396
LA en
DS RISalud
RD Apr 7, 2025