RT Journal Article
T1 Psychometric study of the SF-36v2 in hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE).
A1 Palao-Ocharan, Paola
A1 Prior, Nieves
A1 Pérez-Fernández, Elia
A1 Caminoa, Magdalena
A1 DV-HAE-QoL Study Group, 
A1 Caballero, Teresa
K1 C1-inhibitor
K1 HAE-QoL
K1 Hereditary angioedema
K1 Psychometric study
K1 Quality of life
K1 Questionnaire
K1 SF-36v2
AB The generic 36-item Short-Form Health Survey (SF-36v2) has been used to assess health related quality of life in adult patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) even though it has not yet been validated for use in this specific disease. This study aims to validate the SF-36v2 for use in adult patients with C1-INH-HAE. There was a very low item non-response rate (1-3.4%), with a high ceiling effect in 25/35 items and a low floor effect in 3/35 items. A moderate ceiling effect was observed in 5/8 dimensions of the SF-36v2, whereas no floor effect was noticed in any of the dimensions. Internal consistency was good to excellent with Cronbach's alpha coefficient ranging between 0.82 and 0.93 for the different dimensions. Construct validity was good: seven out of the 8 hypotheses defined on clinical criteria were confirmed, discriminant validity assessment showed significant differences among patients with different C1-INH-HAE severity, convergent validity showed a good correlation among the physical and mental component summaries of the SF-36v2 and the HAE-QoL total score (0.45 and 0.64 respectively, P  The psychometric properties of the SF-36v2 were evaluated in an international setting based on responses from 290 adult C1-INH-HAE patients in 11 countries.
YR 2022
FD 2022-03-02
LK http://hdl.handle.net/10668/20338
UL http://hdl.handle.net/10668/20338
LA en
DS RISalud
RD Apr 7, 2025