RT Journal Article
T1 Structural and functional brain changes in middle-aged type 2 diabetic patients: a cross-sectional study.
A1 García-Casares, Natalia
A1 Berthier, Marcelo L
A1 Jorge, Ricardo E
A1 González-Alegre, Pedro
A1 Gutiérrez Cardo, Antonio
A1 Rioja Villodres, José
A1 Ación, Laura
A1 Ariza Corbo, María José
A1 Nabrozidis, Alejandro
A1 García-Arnés, Juan A
A1 González-Santos, Pedro
K1 Cognition
K1 Magnetic resonance imaging
K1 Neuroimaging
K1 Positron emission tomography
K1 Type 2 diabetes mellitus
K1 Diabetes mellitus tipo 2
K1 Trastornos cognitivos
K1 Trastornos del metabolismo de la glucosa
K1 Enfermedades Vasculares
K1 Neuroimagen
K1 Imagen por resonancia magnética
K1 Tomografía de emisión de positrones
K1 Lóbulo temporal
AB BACKGROUNDType 2 diabetes mellitus (T2DM) is an emerging risk factor for cognitive impairment. Whether this impairment is a direct effect of this metabolic disorder on brain function, a consequence of vascular disease, or both, remains unknown. Structural and functional neuroimaging studies in patients with T2DM could help to elucidate this question.OBJECTIVEWe designed a cross-sectional study comparing 25 T2DM patients with 25 age- and gender-matched healthy control participants. Clinical information, APOE genotype, lipid and glucose analysis, structural cerebral magnetic resonance imaging including voxel-based morphometry, and F-18 fluorodeoxyglucose positron emission tomography were obtained in all subjects.METHODSGray matter densities and metabolic differences between groups were analyzed using statistical parametric mapping. In addition to comparing the neuroimaging profiles of both groups, we correlated neuroimaging findings with HbA1c levels, duration of T2DM, and insulin resistance measurement (HOMA-IR) in the diabetic patients group. Results: Patients with T2DM presented reduced gray matter densities and reduced cerebral glucose metabolism in several fronto-temporal brain regions after controlling for various vascular risk factors. Furthermore, within the T2DM group, longer disease duration, and higher HbA1c levels and HOMA-IR were associated with lower gray matter density and reduced cerebral glucose metabolism in fronto-temporal regions.CONCLUSIONIn agreement with previous reports, our findings indicate that T2DM leads to structural and metabolic abnormalities in fronto-temporal areas. Furthermore, they suggest that these abnormalities are not entirely explained by the role of T2DM as a cardiovascular risk factor.
PB IOS Press
SN 1387-2877
YR 2014
FD 2014-06
LK http://hdl.handle.net/10668/1712
UL http://hdl.handle.net/10668/1712
LA en
NO García-Casares N, Berthier ML, Jorge RE, Gonzalez-Alegre P, Gutiérrez Cardo A, Rioja Villodres J, et al. Structural and functional brain changes in middle-aged type 2 diabetic patients: a cross-sectional study. J. Alzheimers Dis. 2014; 40(2):375-86
NO Journal Article;
DS RISalud
RD Mar 4, 2025