TY  - JOUR
AU  - Vidal, Isabel
AU  - Castilla, Laura
AU  - Marrero, Ana Dácil
AU  - Bravo-Ruiz, Inés
AU  - Bernal, Manuel
AU  - Manrique, Inmaculada
AU  - R Quesada, Ana
AU  - Medina, Miguel Ángel
AU  - Martínez-Poveda, Beatriz
PY  - 2022
DO  - 10.3390/md20100605
UR  - http://hdl.handle.net/10668/21418
T2  - Marine drugs
AB  - (+)-Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and in vivo and modulating the...
LA  - en
KW  - NF-κB pathway
KW  - PI3K/Akt pathway
KW  - aeroplysinin-1
KW  - atherosclerosis
KW  - endothelial cells
KW  - inflammation
KW  - marine-sponge-derived metabolites
KW  - Animals
KW  - Humans
KW  - NF-kappa B
KW  - Tumor Necrosis Factor-alpha
KW  - I-kappa B Kinase
KW  - Lipopolysaccharides
KW  - Proto-Oncogene Proteins c-akt
KW  - Porifera
KW  - Signal Transduction
KW  - Human Umbilical Vein Endothelial Cells
KW  - Anti-Inflammatory Agents
TI  - The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway.
TY  - research article
VL  - 20
ER  -