TY  - JOUR
AU  - Ye, Hui
AU  - Chen, Chaobo
AU  - Wu, Hanghang
AU  - Zheng, Kang
AU  - Martín-Adrados, Beatriz
AU  - Caparros, Esther
AU  - Francés, Rubén
AU  - Nelson, Leonard J
AU  - Gómez Del Moral, Manuel
AU  - Asensio, Iris
AU  - Vaquero, Javier
AU  - Bañares, Rafael
AU  - Ávila, Matías A
AU  - Andrade, Raúl J
AU  - Isabel Lucena, M
AU  - Martínez-Chantar, Maria Luz
AU  - Reeves, Helen L
AU  - Masson, Steven
AU  - Blumberg, Richard S
AU  - Gracia-Sancho, Jordi
AU  - Nevzorova, Yulia A
AU  - Martínez-Naves, Eduardo
AU  - Cubero, Francisco Javier
PY  - 2022
DO  - 10.1038/s41419-022-04580-8
UR  - http://hdl.handle.net/10668/19527
T2  - Cell death & disease
AB  - Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, the mechanisms underlying ER stress remain poorly understood, thus reducing the options for...
LA  - en
KW  - Acetaminophen
KW  - Animals
KW  - Autophagy
KW  - Chemical and Drug Induced Liver Injury
KW  - Cytochrome P-450 CYP2E1
KW  - Hepatocytes
KW  - Humans
KW  - Liver
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - X-Box Binding Protein 1
TI  - Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
TY  - research article
VL  - 13
ER  -