RT Journal Article
T1 Chrono-Nutrition, Chrono-Type, and the Prevalence of Type 2 Diabetes Mellitus in a Cross-Sectional Study from the EuroPean Prospective Investigation into Cancer and Nutrition (EPIC) Study.
A1 Lujan-Barroso, Leila
A1 Margara-Escudero, Hernando J
A1 Crous-Bou, Marta
A1 Huerta, Jose Maria
A1 Chirlaque, Maria-Dolores
A1 Molina-Montes, Esther
A1 Sanchez-Perez, Maria-Jose
A1 Guevara, Marcela
A1 Moreno-Iribas, Conchi
A1 Amiano, Pilar
A1 Mokoroa, Olatz
A1 Gonzalez, Sonia
A1 Agudo, Antonio
A1 Quiros, Jose Ramon
A1 Jakszyn, Paula
K1 EPIC-Spain
K1 Chrono-nutrition
K1 Macronutrients
K1 Meal timing
K1 Type 2 diabetes
AB Previous studies have shown that meal timing, poor sleep quality, and chronotype may play a relevant role in the development of type 2 diabetes mellitus (T2DM). However, its relationship with macronutrients by eating occasions has not been explored deeply. : Our aim was to estimate the association between chrono-nutrition, sleep quality, chronotype, and the prevalence of T2DM. : This cross-sectional study included a subset of 3465 middle-aged Caucasian adults (2068 women) from the European Prospective Investigation into Cancer and Nutrition (EPIC) Spain cohort study. In the 2017-18 follow-up, we assessed chronotype, sleep quality, diet, and sociodemographic data using validated questionnaires. Further, we used blood samples to determine serum levels of glucose. We defined a case of T2DM when serum glucose concentration was ≥126 mg/dL or when participants self-reported diabetes. : A higher prevalence of T2DM was associated with poor sleep quality (OR = 2.90, 95% CI = 1.30, 6.28). Carbohydrate intake at breakfast was inversely associated with the prevalence of T2DM (OR = 0.75, 95% CI = 0.66, 0.85). Finally, lipid intake at breakfast was associated with a 13% higher prevalence of T2DM (OR = 1.13, 95% CI = 1.01, 1.26) for each 1 standard deviation (1-SD) increase. : This study concludes that a higher content of carbohydrates at breakfast is correlated with a reduced prevalence of T2DM, while higher lipids intake at breakfast is associated with a higher prevalence of T2DM. Furthermore, poor sleep quality is a potential factor associated with an elevated prevalence of T2DM. Our results emphasize the need for prospective studies to validate and strengthen these observed associations.
PB MDPI Publishing
YR 2024
FD 2024-08-07
LK https://hdl.handle.net/10668/24324
UL https://hdl.handle.net/10668/24324
LA en
NO Luján-Barroso L, Margara-Escudero HJ, Crous-Bou M, Huerta JM, Chirlaque MD, Molina-Montes E, et al. Chrono-Nutrition, Chrono-Type, and the Prevalence of Type 2 Diabetes Mellitus in a Cross-Sectional Study from the EuroPean Prospective Investigation into Cancer and Nutrition (EPIC) Study. Nutrients. 2024 Aug 7;16(16):2598.
NO This study was supported by the Spanish “Fondo de Investigaciones Sanitarias” (FIS), Instituto de Salud Carlos III (PI15/00347; PI15/01752; PI15/00579; PI15/02181; PI15/01658), and the Marató TV3 (201604–10). The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The EPIC-Spain cohort is supported by the Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), the Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO.
DS RISalud
RD Apr 11, 2025