RT Journal Article
T1 Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC).
A1 Smith, Karl
A1 Byrne, 
A1 Castaño, Jose Maria
A1 Chirlaque, Maria Dolores
A1 Lilja, Hans
A1 Agudo, Antonio
A1 Ardanaz, Eva
A1 Rodríguez-Barranco, Miguel
A1 Boeing, Heiner
A1 Kaaks, Rudolf
A1 Khaw, Kay-Tee
A1 Larrañaga, Nerea
A1 Navarro, Carmen
A1 Olsen, Anja
A1 Overvad, Kim
A1 Perez-Cornago, Aurora
A1 Rohrmann, Sabine
A1 Sánchez, Maria José
A1 Tjønneland, Anne
A1 Tsilidis, Konstantinos K
A1 Johansson, Mattias
A1 Riboli, Elio
A1 Key, Timothy J
A1 Travis, Ruth C
AB Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. Patients and Methods A total of 84,753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate cancer risk overall, by tumor subtype, and for death due to prostate cancer, using multivariable-adjusted Cox proportional hazards models. Results During an average follow-up of 15.4 years, 4,377 men were diagnosed with prostate cancer, including 641 who had undergone a vasectomy. Vasectomy was not associated with prostate cancer risk (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.15), and no evidence for heterogeneity in the association was observed by stage of disease or years since vasectomy. There was some evidence of heterogeneity by tumor grade ( P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07). Vasectomy was not associated with death due to prostate cancer (HR, 0.88; 95% CI, 0.68 to 1.12). Conclusion These findings from a large European prospective study show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to prostate cancer in men who have undergone a vasectomy compared with men who have not.
YR 2017
FD 2017-03-06
LK http://hdl.handle.net/10668/11051
UL http://hdl.handle.net/10668/11051
LA en
DS RISalud
RD Apr 7, 2025