RT Journal Article
T1 Challenges and achievements of liquid biopsy technologies employed in early breast cancer
A1 Alba-Bernal, Alfonso
A1 Lavado-Valenzuela, Rocío
A1 Domínguez-Recio, María Emilia
A1 Jiménez-Rodriguez, Begoña
A1 Queipo-Ortuño, María Isabel
A1 Alba, Emilio
A1 Comino-Méndez, Iñaki
K1 Liquid biopsy
K1 Localized breast cancer
K1 Circulating-tumour DNA
K1 Circulating-tumour cells
K1 Circulating-tumour RNA
K1 Biopsia líquida
K1 Neoplasias de la mama
K1 ARN
K1 ADN
K1 Células
K1 ARN Circular
K1 Pacientes
AB Breast cancer is the most common cancer type in women worldwide and its early detection is crucial to curing the disease. Tissue biopsy, currently the method of choice to obtain tumour molecular information, is invasive and might be affected by tumour heterogeneity rendering it incapable to portray the complete molecular picture. Liquid biopsy permits to study disease features in a more comprehensive manner by sampling biofluids and extracting tumour components such as circulating-tumour DNA (ctDNA), circulating-tumour cells (CTCs), and/or circulating-tumour RNA (ctRNA) amongst others in a monitoring-compatible manner. In this review, we describe the recent progress in the utilization of the circulating tumour components using early breast cancer samples. We review the most important analytes and technologies employed for their study.
PB Elsevier
YR 2020
FD 2020-11-09
LK http://hdl.handle.net/10668/3766
UL http://hdl.handle.net/10668/3766
LA en
NO Alba-Bernal A, Lavado-Valenzuela R, Domínguez-Recio ME, Jiménez-Rodriguez B, Queipo-Ortuño MI, Alba E, et al. Challenges and achievements of liquid biopsy technologies employed in early breast cancer. EBioMedicine. 2020 Dec;62:103100
DS RISalud
RD Apr 11, 2025