TY - JOUR AU - Provencio, Mariano AU - Serna-Blasco, Roberto AU - Franco, Fabio AU - Calvo, Virgina AU - Royuela, Ana AU - Auglytė, Milda AU - Sánchez-Hernández, Alfredo AU - de Julián Campayo, María AU - García-Girón, Carlos AU - Dómine, Manuel AU - Blasco, Ana AU - Sánchez, José M AU - Oramas, Juana AU - Bosch-Barrera, Joaquim AU - Sala, María Á AU - Sereno, María AU - Ortega, Ana L AU - Chara, Luis AU - Hernández, Berta AU - Padilla, Airam AU - Coves, Juan AU - Blanco, Remedios AU - Balsalobre, José AU - Mielgo, Xabier AU - Bueno, Coralia AU - Jantus-Lewintre, Eloisa AU - Molina-Vila, Miguel Á AU - Romero, Atocha PY - 2021 DO - 10.1016/j.ejca.2021.02.031 UR - http://hdl.handle.net/10668/17547 T2 - European journal of cancer (Oxford, England : 1990) AB - Survival data support the use of first-line osimertinib as the standard of care for epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC). However, it remains unclear whether upfront osimertinib is superior to sequential... LA - en KW - EGFR KW - NSCLC KW - Osimertinib KW - TKI KW - ctDNA KW - Acrylamides KW - Aged KW - Aniline Compounds KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - Carcinoma, Non-Small-Cell Lung KW - Circulating Tumor DNA KW - Clinical Decision-Making KW - Cross-Sectional Studies KW - DNA Mutational Analysis KW - ErbB Receptors KW - Female KW - Humans KW - Lung Neoplasms KW - Male KW - Middle Aged KW - Mutation KW - Neoplasm Staging KW - Polymerase Chain Reaction KW - Predictive Value of Tests KW - Prospective Studies KW - Protein Kinase Inhibitors KW - Spain KW - Time Factors KW - Treatment Outcome TI - Analysis of circulating tumour DNA to identify patients with epidermal growth factor receptor-positive non-small cell lung cancer who might benefit from sequential tyrosine kinase inhibitor treatment. TY - research article VL - 149 ER -