RT Journal Article
T1 Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis
A1 Cruz-Gomez, Álvaro J.
A1 Forero, Lucía
A1 Lozano-Soto, Elena
A1 Cano-Cano, Fátima
A1 Sanmartino, Florencia
A1 Rashid-López, Raúl
A1 Paz-Expósito, Jsé
A1 Gómez Ramirez, Jaime D.
A1 Espinosa-Rosso, Raúl
A1 González-Rosa, Javier J.
K1 Cortical thickness
K1 Multiple sclerosis
K1 Cognitive dysfunction
K1 Serum
K1 Brain
K1 Serum neurofilament light chain (sNfL)
K1 Hueso cortical
K1 Esclerosis múltiple
K1 Disfunción cognitiva
K1 Suero
K1 Encéfalo
AB Background and Objectives To determine the relative importance of global or regional MRI and blood markers of neu rodegeneration and neuroaxonal injury in predicting cognitive performance for recently di agnosed patients with multiple sclerosis (MS). Methods Thirty-five newly diagnosed patients with relapsing-remitting MS (RRMS) and 23 healthy controls (HCs) simultaneously completed a full clinical and neuropsychological assessment, structural brain MRI, and serum neurofilament light chain (sNfL) level test. Linear regression analyses were performed to determine which global or regional measures of gray matter (GM) atrophy and cortical thickness (CT), in combination with sNfL levels and clinical scores, are most strongly related to neuropsychological impairment. Results Compared with HCs, patients with MS showed bilateral thalamic GM atrophy (left, p = 0.033; right, p = 0.047) and diminished CT, particularly in the right superior and transverse temporal gyri (p = 0.045; p = 0.037). Regional atrophy failed to add predictive variance, whereas anxiety symptoms, sNfL, and global CT were the best predictors (R2 = 0.404; p < 0.001) of cognitive outcomes, with temporal thickness accounting for greater variance in cognitive deficits than global CT. Discussion Thalamic GM atrophy and thinning in temporal regions represent a distinctive MRI trait in the early stages of MS. Although sNfL levels alone do not clearly differentiate HCs and patients with RRMS, in combination with global and regional CT, sNfL levels can better explain the presence of underlying cognitive deficits. Hence, cortical thinning and sNfL increases can be considered 2 parallel neurodegenerative markers in the pathogenesis of progression in newly diagnosed patients with MS.
PB Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
YR 2021
FD 2021
LK http://hdl.handle.net/10668/4228
UL http://hdl.handle.net/10668/4228
LA en
NO Cruz-Gomez ÁJ, Forero L, Lozano-Soto E, Cano-Cano F, Sanmartino F, Rashid-López R, el al. Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Aug 31;8(6):e1074
DS RISalud
RD Apr 17, 2025