RT Journal Article
T1 Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.
A1 Serena, Carolina
A1 Ceperuelo-Mallafre, Victoria
A1 Keiran, Noelia
A1 Queipo-Ortuño, Maria Isabel
A1 Bernal, Rosa
A1 Gomez-Huelgas, Ricardo
A1 Urpi-Sarda, Mireia
A1 Sabater, Monica
A1 Perez-Brocal, Vicente
A1 Andres-Lacueva, Cristina
A1 Moya, Andres
A1 Tinahones, Francisco J
A1 Fernandez-Real, Jose Manuel
A1 Vendrell, Joan
A1 Fernandez-Veledo, Sonia
K1 Bacteria
K1 Biomarkers
K1 Cross-Sectional Studies
K1 Diabetes Mellitus, Type 2
AB Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects. Obesity was associated with elevated levels of circulating succinate concomitant with impaired glucose metabolism. This increase was associated with specific changes in gut microbiota related to succinate metabolism: a higher relative abundance of succinate-producing Prevotellaceae (P) and Veillonellaceae (V), and a lower relative abundance of succinate-consuming Odoribacteraceae (O) and Clostridaceae (C) in obese individuals, with the (P + V/O + C) ratio being a main determinant of plasma succinate. Weight loss intervention decreased (P + V/O + C) ratio coincident with the reduction in circulating succinate. In the spontaneous evolution after good dietary advice, alterations in circulating succinate levels were linked to specific metagenomic signatures associated with carbohydrate metabolism and energy production with independence of body weight change. Our data support the importance of microbe-microbe interactions for the metabolite signature of gut microbiome and uncover succinate as a potential microbiota-derived metabolite related to CVD risk.
PB Oxford University Press
YR 2018
FD 2018-02-12
LK http://hdl.handle.net/10668/12118
UL http://hdl.handle.net/10668/12118
LA en
NO Serena C, Ceperuelo-Mallafré V, Keiran N, Queipo-Ortuño MI, Bernal R, Gomez-Huelgas R, et al. Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ISME J. 2018 Jun;12(7):1642-1657
DS RISalud
RD Apr 6, 2025