%0 Journal Article
%A Alonso, S
%A Riveiro-Barciela, M
%A Fernandez, I
%A Rincon, D
%A Real, Y
%A Llerena, S
%A Gea, F
%A Olveira, A
%A Fernandez-Carrillo, C
%A Polo, B
%A Carrion, J A
%A Gomez, A
%A Devesa, M J
%A Baliellas, C
%A Castro, A
%A Ampuero, J
%A Granados, R
%A Pascasio, J M
%A Rubin, A
%A Salmeron, J
%A Badia, E
%A Planas, J M M
%A Lens, S
%A Turnes, J
%A Montero, J L
%A Buti, M
%A Esteban, R
%A Fernandez-Rodriguez, C M
%T Effectiveness and safety of sofosbuvir-based regimens plus an NS5A inhibitor for patients with HCV genotype 3 infection and cirrhosis. Results of a multicenter real-life cohort.
%D 2017
%U http://hdl.handle.net/10668/10667
%X Patients with HCV genotype 3 (GT3) infection and cirrhosis are currently the most difficult to cure . We report our experience with sofosbuvir +daclatasvir (SOF+DCV) or sofosbuvir /ledipasvir (SOF/LDV), with or without ribavirin (RBV) in clinical practice in this population . This was a multicenter observational study including cirrhotic patients infected by HCV GT3, treated with sofosbuvir plus an NS5A inhibitor (May 2014-October 2015). In total, 208 patients were included: 98 (47%) treatment -experienced, 42 (20%) decompensated and 55 (27%) MELD score >10. In 131 (63%), treatment was SOF+DCV and in 77 (37%), SOF/LDV. Overall, 86% received RBV. RBV addition and extension to 24 weeks was higher in the SOF/LDV group (95% vs 80%, P=.002 and 83% vs 72%, P=.044, respectively). A higher percentage of decompensated patients were treated with DCV than LDV (25% vs 12%, P=.013). Overall, SVR12 was 93.8% (195/208): 94% with SOF+DCV and 93.5% with SOF/LDV. SVR12 was achieved in 90.5% of decompensated patients . Eleven treatment failures : 10 relapses and one breakthrough. RBV addition did not improve SVR (RR: 1.08; P=.919). The single factor associated with failure to achieve SVR was platelet count <75×10E9/mL (RR: 3.50, P=.019). In patients with MELD <10, type of NS5A inhibitor did not impact on SVR12 (94% vs 97%; adjusted RR: 0.49). Thirteen patients (6.3%) had serious adverse events, including three deaths (1.4%) and one therapy discontinuation (0.5%), higher in decompensated patients (16.7% vs 3.6%, P<.006). In patients with GT3 infection and cirrhosis , SVR12 rates were high with both SOF+DCV and SOF/LDV, with few serious adverse events.
%K SVR12
%K cirrhosis
%K daclatasvir
%K genotype 3
%K hepatitis C
%K ledipasvir
%K observational study
%K real-world cohort
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