RT Journal Article
T1 Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study.
A1 Gonzalez-Gil, Esther M
A1 Anguita-Ruiz, Augusto
A1 Kalen, Anton
A1 De Las Lamas Perez, Carmela
A1 Ruperez, Azahara I
A1 Vazquez-Cobela, Rocio
A1 Flores, Katherine
A1 Gil, Angel
A1 Gil-Campos, Mercedes
A1 Bueno, Gloria
A1 Leis, Rosaura
A1 Aguilera, Concepcion M
K1 Cardiovascular risk
K1 Inflammation
K1 Metabolic syndrome
K1 Puberty
AB Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4-18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p  Those with obesity with higher prepubertal tPAI plasma levels had 19% higher odds of having MetS at puberty highlighting the existence of association between MetS, obesity, and inflammation already in puberty. Thus, assessing cardiometabolic and inflammatory status in children with obesity already at prepuberty is key to avoiding future comorbidities. • Inflammation, metabolic syndrome, and obesity may have their onset in childhood. • Puberty is a life stage characterized for an increased cardiovascular risk. • Prepuberty state could be an early indicator of future cardiometabolic risk. • Children with obesity and high total plasminogen have higher odds of future metabolic syndrome.
PB Springer
YR 2022
FD 2022-11-06
LK http://hdl.handle.net/10668/20208
UL http://hdl.handle.net/10668/20208
LA en
NO González-Gil EM, Anguita-Ruiz A, Kalén A, De Las Lamas Perez C, Rupérez AI, Vázquez-Cobela R, et al. Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study. Eur J Pediatr. 2023 Jan;182(1):419-429
DS RISalud
RD Apr 9, 2025