RT Journal Article
T1 Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial.
A1 Diaz-Lopez, Andres
A1 Becerra-Tomas, Nerea
A1 Ruiz, Veronica
A1 Toledo, Estefania
A1 Babio, Nancy
A1 Corella, Dolores
A1 Fito, Montse
A1 Romaguera, Dora
A1 Vioque, Jesus
A1 Alonso-Gomez, Angel M
A1 Wärnberg, Julia
A1 Martinez, J Alfredo
A1 Serra-Majem, Luis
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, Jose
A1 Pinto, Xavier
A1 Tur, Josep A
A1 Lopez-Miranda, Jose
A1 Cano Ibañez, Naomi
A1 Delgado-Rodriguez, Miguel
A1 Matia-Martin, Pilar
A1 Daimiel, Lidia
A1 de Paz, Jose Antonio
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Ruiz-Canela, Miguel
A1 Bullo, Monica
A1 Sorli, Jose V
A1 Goday, Albert
A1 Fiol, Miquel
A1 Garcia-de-la-Hera, Manoli
A1 Tojal Sierra, Lucas
A1 Perez-Farinos, Napoleon
A1 Zulet, Maria Angeles
A1 Sanchez-Villegas, Almudena
A1 Sacanella, Emilio
A1 Fernandez-Garcia, Jose Carlos
A1 Santos-Lozano, Jose Manuel
A1 Gimenez-Gracia, Miquel
A1 Del Mar Bibiloni, Maria
A1 Diez-Espino, Javier
A1 Ortega-Azorin, Carolina
A1 Castañer, Olga
A1 Morey, Marga
A1 Torres-Collado, Laura
A1 Sorto Sanchez, Carolina
A1 Muñoz, Miguel Angel
A1 Ros, Emilio
A1 Martinez-Gonzalez, Miguel A
A1 Salas-Salvado, Jordi
K1 Dietary intervention
K1 Glomerular filtration rate
K1 Kidney function
K1 Mediterranean diet
K1 PREDIMED-Plus
K1 Weight loss
AB Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Randomized controlled "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR ( After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
PB S. Karger
YR 2021
FD 20210-12-01
LK http://hdl.handle.net/10668/17123
UL http://hdl.handle.net/10668/17123
LA en
NO Díaz-López A, Becerra-Tomás N, Ruiz V, Toledo E, Babio N, Corella D, et al. Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial. Am J Nephrol. 2021;52(1):45-58
DS RISalud
RD Apr 10, 2025