%0 Journal Article
%A Diaz-Lopez, Andres
%A Becerra-Tomas, Nerea
%A Ruiz, Veronica
%A Toledo, Estefania
%A Babio, Nancy
%A Corella, Dolores
%A Fito, Montse
%A Romaguera, Dora
%A Vioque, Jesus
%A Alonso-Gomez, Angel M
%A Wärnberg, Julia
%A Martinez, J Alfredo
%A Serra-Majem, Luis
%A Estruch, Ramon
%A Tinahones, Francisco J
%A Lapetra, Jose
%A Pinto, Xavier
%A Tur, Josep A
%A Lopez-Miranda, Jose
%A Cano Ibañez, Naomi
%A Delgado-Rodriguez, Miguel
%A Matia-Martin, Pilar
%A Daimiel, Lidia
%A de Paz, Jose Antonio
%A Vidal, Josep
%A Vazquez, Clotilde
%A Ruiz-Canela, Miguel
%A Bullo, Monica
%A Sorli, Jose V
%A Goday, Albert
%A Fiol, Miquel
%A Garcia-de-la-Hera, Manoli
%A Tojal Sierra, Lucas
%A Perez-Farinos, Napoleon
%A Zulet, Maria Angeles
%A Sanchez-Villegas, Almudena
%A Sacanella, Emilio
%A Fernandez-Garcia, Jose Carlos
%A Santos-Lozano, Jose Manuel
%A Gimenez-Gracia, Miquel
%A Del Mar Bibiloni, Maria
%A Diez-Espino, Javier
%A Ortega-Azorin, Carolina
%A Castañer, Olga
%A Morey, Marga
%A Torres-Collado, Laura
%A Sorto Sanchez, Carolina
%A Muñoz, Miguel Angel
%A Ros, Emilio
%A Martinez-Gonzalez, Miguel A
%A Salas-Salvado, Jordi
%T Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial.
%D 0210
%U http://hdl.handle.net/10668/17123
%X Large randomized trials testing the effect of a multifactorial weight-loss lifestyle intervention including Mediterranean diet (MedDiet) on renal function are lacking. Here, we evaluated the 1-year efficacy of an intensive weight-loss intervention with an energy-reduced MedDiet (erMedDiet) plus increased physical activity (PA) on renal function. Randomized controlled "PREvención con DIeta MEDiterránea-Plus" (PREDIMED-Plus) trial is conducted in 23 Spanish centers comprising 208 primary care clinics. Overweight/obese (n = 6,719) adults aged 55-75 years with metabolic syndrome were randomly assigned (1:1) to an intensive weight-loss lifestyle intervention with an erMedDiet, PA promotion, and behavioral support (intervention) or usual-care advice to adhere to an energy-unrestricted MedDiet (control) between September 2013 and December 2016. The primary outcome was 1-year change in estimated glomerular filtration rate (eGFR). Secondary outcomes were changes in urine albumin-to-creatinine ratio (UACR), incidence of moderately/severely impaired eGFR ( After 1 year, eGFR declined by 0.66 and 1.25 mL/min/1.73 m2 in the intervention and control groups, respectively (mean difference, 0.58 mL/min/1.73 m2; 95% CI: 0.15-1.02). There were no between-group differences in mean UACR or micro- to macroalbuminuria changes. Moderately/severely impaired eGFR incidence and reversion of moderately to mildly impaired GFR were 40% lower (HR 0.60; 0.44-0.82) and 92% higher (HR 1.92; 1.35-2.73), respectively, in the intervention group. The PREDIMED-Plus lifestyle intervention approach may preserve renal function and delay CKD progression in overweight/obese adults.
%K Dietary intervention
%K Glomerular filtration rate
%K Kidney function
%K Mediterranean diet
%K PREDIMED-Plus
%K Weight loss
%~