RT Journal Article
T1 Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
A1 Rubín-García, María
A1 Vitelli-Storelli, Facundo
A1 Molina, Antonio José
A1 Zamora-Ros, Raúl
A1 Aragonés, Nuria
A1 Adarnaz, Eva
A1 Castaño-Vinyals, Gemma
A1 Obón-Santacana, Mireia
A1 Gómez-Acebo, Inés
A1 Molina-Barceló, Ana
A1 Fernández-Tardón, Guillermo
A1 Jiménez-Moleón, José J.
A1 Alguacil, Juan
A1 Chirlaque, María Dolores
A1 Toledo, Estefanía
A1 Pérez-Gómez, Beatriz
A1 Pollán, Marina
A1 Kogevinas, Manolis
A1 Martín, Vicente
K1 Diet
K1 Epidemiology
K1 Gastric cancer
K1 Polyphenols
K1 Phenolic acids
K1 Stilbenes
K1 Lignans
K1 Anatomic
K1 Histologic
K1 MCC-Spain
K1 Dieta
K1 Epidemiología
K1 Neoplasias gástricas
K1 Polifenoles
K1 Compuestos fenólicos
K1 Estilbenos
K1 Lignanos
AB Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
PB MDPI
YR 2020
FD 2020-10-26
LK http://hdl.handle.net/10668/3841
UL http://hdl.handle.net/10668/3841
LA en
NO Rubín-García M, Vitelli-Storelli F, Molina AJ, Zamora-Ros R, Aragonés N, Adarnaz E, et al. Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain. Nutrients. 2020 Oct 26;12(11):3281
DS RISalud
RD Apr 8, 2025