RT Journal Article T1 Influence of gender and education on cocaine users in an outpatient cohort in Spain A1 Requena-Ocaña, Nerea A1 Flores-Lopez, María A1 San Martín, Alicia A1 García-Marchena, Nuria A1 Pedraz, María A1 Ruiz, Juan Jesús A1 Serrano, Antonia A1 Suarez, Juan A1 Pavón, Francisco Javier A1 Rodríguez de Fonseca, Fernando A1 Araos, Pedro K1 Alcoholism K1 Cocaine-related disorders K1 Anxiety disorders K1 Major depressive disorder K1 Outpatients K1 Prevalence K1 Social class K1 Gender studies K1 Education K1 Spain K1 Alcoholismo K1 Trastornos relacionados con cocaína K1 Trastornos de ansiedad K1 Trastorno depresivo mayor K1 Pacientes ambulatorios K1 Prevalencia K1 Clase social K1 Estudios de género K1 Educación K1 España AB Gender significantly influences sociodemographic, medical, psychiatric and addiction variables in cocaine outpatients. Educational level may be a protective factor showing less severe addictive disorders, longer abstinence periods, and better cognitive performance. The aim was to estimate gender-based differences and the influence of educational level on the clinical variables associated with cocaine use disorder (CUD). A total of 300 cocaine-consuming patients undergoing treatments were recruited and assessed using the Psychiatric Research Interview for Substance and Mental Diseases according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Women developed CUD later but exhibited more consumption of anxiolytics, prevalence of anxiety disorders, eating disorders, and major depressive disorders. Alcohol and cannabis use disorders were more frequent in men. A predictive model was created and identified three psychiatric variables with good prognosis for distinguishing between women and men. Principal component analysis helped to describe the different profile types of men and women who had sought treatment. Low educational levels seemed to be a risk factor for the onset, development, and duration of CUD in both genders. Women and men exhibited different clinical characteristics that should be taken into account when designing therapeutic policies. The educational level plays a protective/risk role in the onset, development and progression of CUD, thus prolonging the years of compulsory education and implementing cognitive rehabilitation programmes could be useful. PB Springer Nature YR 2021 FD 2021-10-22 LK http://hdl.handle.net/10668/4474 UL http://hdl.handle.net/10668/4474 LA en NO Requena-Ocaña N, Flores-Lopez M, Martín AS, García-Marchena N, Pedraz M, Ruiz JJ, et al. Influence of gender and education on cocaine users in an outpatient cohort in Spain. Sci Rep. 2021 Oct 22;11(1):20928 DS RISalud RD Apr 9, 2025