RT Journal Article
T1 Relationship between plasma S-Klotho and cardiometabolic risk in sedentary adults.
A1 Amaro-Gahete, Francisco J
A1 Jurado-Fasoli, Lucas
A1 Sanchez-Delgado, Guillermo
A1 García-Lario, José V
A1 Castillo, Manuel J
A1 Ruiz, Jonatan R
K1 aging
K1 biomarker
K1 cholesterol
K1 glucose
K1 insulin sensitivity
AB This cross-sectional study investigates the relationship between the shed form of the Klotho protein (S-Klotho) in plasma, and cardiometabolic risk in healthy, sedentary adults. The study subjects were 214 healthy, sedentary adults (~64% women). Data were collected during the baseline assessments of two randomized controlled trials: The FIT-AGEING study (n=74 [~50% women] middle-aged adults aged 40-65 years) and the ACTIBATE study (n=140 [~70% women] young adults aged 18-25 years). A sex-specific cardiometabolic risk score was calculated for each subject based on waist circumference, systolic and diastolic blood pressure, and plasma glucose, high-density lipoprotein cholesterol and triglycerides. A significant inverse relationship was detected between S-Klotho and the cardiometabolic risk score of both the middle-aged men and women (β=-0.658, R2=0.433, P0.5), nor for the young, healthy men and women when analysed separately (all P>0.1). In conclusion, in healthy, sedentary, middle-aged adults, but not in young, healthy, sedentary adults, higher plasma S-Klotho concentrations are associated with a lower cardiometabolic risk score.
YR 2020
FD 2020-01-20
LK http://hdl.handle.net/10668/14970
UL http://hdl.handle.net/10668/14970
LA en
DS RISalud
RD Apr 18, 2025