RT Journal Article T1 Circulating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort. A1 van Roekel, Eline H A1 Trijsburg, Laura A1 Assi, Nada A1 Carayol, Marion A1 Achaintre, David A1 Murphy, Neil A1 Rinaldi, Sabina A1 Schmidt, Julie A A1 Stepien, Magdalena A1 Kaaks, Rudolf A1 Kühn, Tilman A1 Boeing, Heiner A1 Iqbal, Khalid A1 Palli, Domenico A1 Krogh, Vittorio A1 Tumino, Rosario A1 Ricceri, Fulvio A1 Panico, Salvatore A1 Peeters, Petra H A1 Bueno-de-Mesquita, Bas A1 Ardanaz, Eva A1 Lujan-Barroso, Leila A1 Quirós, J Ramón A1 Huerta, José M A1 Molina-Portillo, Elena A1 Dorronsoro, Miren A1 Tsilidis, Konstantinos K A1 Riboli, Elio A1 Rostgaard-Hansen, Agnetha Linn A1 Tjønneland, Anne A1 Overvad, Kim A1 Weiderpass, Elisabete A1 Boutron-Ruault, Marie-Christine A1 Severi, Gianluca A1 Trichopoulou, Antonia A1 Karakatsani, Anna A1 Kotanidou, Anastasia A1 Håkansson, Anders A1 Malm, Johan A1 Weijenberg, Matty P A1 Gunter, Marc J A1 Jenab, Mazda A1 Johansson, Mattias A1 Travis, Ruth C A1 Scalbert, Augustin A1 Ferrari, Pietro K1 acylcarnitines K1 alcohol K1 amino acids K1 lipid metabolites K1 targeted metabolomics AB Identifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value YR 2018 FD 2018-05-22 LK http://hdl.handle.net/10668/12500 UL http://hdl.handle.net/10668/12500 LA en DS RISalud RD Feb 18, 2025