RT Journal Article
T1 Repeating with the right hemisphere: reduced interactions between phonological and lexical-semantic systems in crossed aphasia?
A1 De-Torres, Irene
A1 Dávila, Guadalupe
A1 Berthier, Marcelo L.
A1 Froudist Walsh, Seán
A1 Moreno-Torres, Ignacio
A1 Ruiz-Cruces, Rafael
K1 Right hemisphere
K1 Languaje
K1 Crossed Aphasia
K1 Conduction Aphasia
K1 Language network
K1 Structural connectivity
K1 Humanos
K1 España
K1 Memoria a corto plazo
K1 Lenguaje
K1 Afasia de conducción
K1 Lóbulo temporal
K1 Trastornos del lenguaje
AB Knowledge on the patterns of repetition amongst individuals who develop language deficits in association with right hemisphere lesions (crossed aphasia) is very limited. Available data indicate that repetition in some crossed aphasics experiencing phonological processing deficits is not heavily influenced by lexical-semantic variables (lexicality, imageability, and frequency) as is regularly reported in phonologically-impaired cases with left hemisphere damage. Moreover, in view of the fact that crossed aphasia is rare, information on the role of right cortical areas and white matter tracts underpinning language repetition deficits is scarce. In this study, repetition performance was assessed in two patients with crossed conduction aphasia and striatal/capsular vascular lesions encompassing the right arcuate fasciculus (AF) and inferior frontal-occipital fasciculus (IFOF), the temporal stem and the white matter underneath the supramarginal gyrus. Both patients showed lexicality effects repeating better words than non-words, but manipulation of other lexical-semantic variables exerted less influence on repetition performance. Imageability and frequency effects, production of meaning-based paraphrases during sentence repetition, or better performance on repeating novel sentences than overlearned clichés were hardly ever observed in these two patients. In one patient, diffusion tensor imaging disclosed damage to the right long direct segment of the AF and IFOF with relative sparing of the anterior indirect and posterior segments of the AF, together with fully developed left perisylvian white matter pathways. These findings suggest that striatal/capsular lesions extending into the right AF and IFOF in some individuals with right hemisphere language dominance are associated with atypical repetition patterns which might reflect reduced interactions between phonological and lexical-semantic processes.
PB Frontiers Research Foundation
YR 2013
FD 2013-10-18
LK http://hdl.handle.net/10668/1546
UL http://hdl.handle.net/10668/1546
LA en
NO De-Torres I, Dávila G, Berthier ML, Froudist Walsh S, Moreno-Torres I, Ruiz-Cruces R. Repeating with the right hemisphere: reduced interactions between phonological and lexical-semantic systems in crossed aphasia? Front Hum Neurosci. 2013; 7:675.
NO Journal Article;
DS RISalud
RD Apr 8, 2025