RT Journal Article T1 A new approach to oxidative stress and inflammatory signaling during labour in healthy mothers and neonates. A1 Díaz-Castro, Javier A1 Florido, Jesus A1 Kajarabille, Naroa A1 Prados, Sonia A1 de Paco, Catalina A1 Ocon, Olga A1 Pulido-Moran, Mario A1 Ochoa, Julio J K1 Catalasa K1 Dinoprostona K1 Femenino K1 Sangre fetal K1 Edad gestacional K1 Glutatión peroxidasa K1 Humanos K1 Recién nacido K1 Interleucina-6 K1 Trabajo de parto K1 Madres K1 Estrés oxidativo K1 Transducción de señal K1 Superóxido dismutasa K1 Factor de necrosis tumoral alfa AB The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates. 56 mothers with normal gestational course and spontaneous delivery were selected. Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord. Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein. There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2 was also increased. Neonates showed lower levels of IL-6 and TNF-α and higher values of sTNF-RII and PGE2 in comparison with their mothers. Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein. The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition. PB Hindawi Publishing Corporation YR 2015 FD 2015 LK http://hdl.handle.net/10668/2567 UL http://hdl.handle.net/10668/2567 LA en NO Díaz-Castro J, Florido J, Kajarabille N, Prados S, de Paco C, Ocon O, et al. A new approach to oxidative stress and inflammatory signaling during labour in healthy mothers and neonates. Oxid Med Cell Longev. 2015;178536 NO Journal Article; DS RISalud RD Feb 15, 2025