RT Journal Article T1 Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study. A1 Ferrari, Pietro A1 Licaj, Idlir A1 Muller, David C A1 Kragh Andersen, Per A1 Johansson, Mattias A1 Boeing, Heiner A1 Weiderpass, Elisabete A1 Dossus, Laure A1 Dartois, Laureen A1 Fagherazzi, Guy A1 Bradbury, Kathryn E A1 Khaw, Kay-Tee A1 Wareham, Nick A1 Duell, Eric J A1 Barricarte, Aurelio A1 Molina-Montes, Esther A1 Navarro Sanchez, Carmen A1 Arriola, Larraitz A1 Wallström, Peter A1 Tjønneland, Anne A1 Olsen, Anja A1 Trichopoulou, Antonia A1 Benetou, Vasiliki A1 Trichopoulos, Dimitrios A1 Tumino, Rosario A1 Agnoli, Claudia A1 Sacerdote, Carlotta A1 Palli, Domenico A1 Li, Kuanrong A1 Kaaks, Rudolf A1 Peeters, Petra A1 Beulens, Joline Wj A1 Nunes, Luciana A1 Gunter, Marc A1 Norat, Teresa A1 Overvad, Kim A1 Brennan, Paul A1 Riboli, Elio A1 Romieu, Isabelle K1 Consumo de bebidas alcohólicas K1 Etanol K1 Neoplasias K1 Estado Nutricional K1 Estudios Prospectivos K1 Europa AB OBJECTIVESTo investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death.DESIGNThe European Prospective Investigation into Cancer and nutrition (EPIC).SETTING23 centres in 10 countries.PARTICIPANTS380 395 men and women, free of cancer, diabetes, heart attack or stroke at enrolment, followed up for 12.6 years on average.MAIN OUTCOME MEASURES20 453 fatal events, of which 2053 alcohol-related cancers (ARC, including cancers of upper aerodigestive tract, liver, colorectal and female breast), 4187 cardiovascular diseases/coronary heart disease (CVD/CHD), 856 violent deaths and injuries. Lifetime alcohol use was assessed at recruitment.RESULTSHRs comparing extreme drinkers (≥30 g/day in women and ≥60 g/day in men) to moderate drinkers (0.1-4.9 g/day) were 1.27 (95% CI 1.13 to 1.43) in women and 1.53 (1.39 to 1.68) in men. Strong associations were observed for ARC mortality, in men particularly, and for violent deaths and injuries, in men only. No associations were observed for CVD/CHD mortality among drinkers, whereby HRs were higher in never compared to moderate drinkers. Overall mortality seemed to be more strongly related to beer than wine use, particularly in men. The 10-year risks of overall death for women aged 60 years, drinking more than 30 g/day was 5% and 7%, for never and current smokers, respectively. Corresponding figures in men consuming more than 60 g/day were 11% and 18%, in never and current smokers, respectively. In competing risks analyses, mortality due to CVD/CHD was more pronounced than ARC in men, while CVD/CHD and ARC mortality were of similar magnitude in women.CONCLUSIONSIn this large European cohort, alcohol use was positively associated with overall mortality, ARC and violent death and injuries, but marginally to CVD/CHD. Absolute risks of death observed in EPIC suggest that alcohol is an important determinant of total mortality. PB BMJ Publishing Group YR 2014 FD 2014-07-03 LK http://hdl.handle.net/10668/1971 UL http://hdl.handle.net/10668/1971 LA en NO Ferrari P, Licaj I, Muller DC, Kragh Andersen P, Johansson M, Boeing H, et al. Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study. BMJ Open 2014; 4(7):e005245 NO Journal Article; DS RISalud RD Apr 10, 2025