RT Journal Article
T1 Real-life analysis on safety and efficacy of asciminib for ponatinib pretreated patients with chronic myeloid leukemia.
A1 Luna, A
A1 Perez-Lamas, L
A1 Boque, C
A1 Giraldo, P
A1 Xicoy, B
A1 Ruiz-Nuño, C
A1 Moreno-Vega, M
A1 Alvarez-Larran, A
A1 Salamanca, A
A1 Garcia-Noblejas, A
A1 Vall-Llovera, F
A1 Villalon, L
A1 De-Las-Heras, N
A1 Ramila, E
A1 Perez-Encinas, M
A1 Cuevas, B
A1 Perez-Lopez, R
A1 Sanchez-Guijo, F
A1 Jimenez-Velasco, A
A1 Lakhwani, S
A1 Casado, L Felipe
A1 Rosell, A
A1 Escola, A
A1 Fernandez, M J
A1 Garcia-Hernandez, C
A1 Cervero, C
A1 Mora, E
A1 Sagues, M
A1 Suarez-Varela, S
A1 Velez, P
A1 Carrascosa Mastell, P
A1 Bitaube, R F
A1 Serrano, L
A1 Cortes, M
A1 Vera-Goñi, J A
A1 Steegmann, J L
A1 Gomez-Garcia-de-Soria, V
A1 Alonso-Dominguez, J M
A1 Colorado-Araujo, M
A1 Coll, A Paz
A1 Hernandez-Boluda, J C
A1 Garcia-Gutierrez, V
K1 Asciminib
K1 Inhibitors
K1 Leukemia
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
AB Failure of second-generation tyrosine kinase inhibitors (2GTKI) is a challenging situation in patients with chronic myeloid leukemia (CML). Asciminib, recently approved by the US Federal Drug Administration, has demonstrated in clinical trials a good efficacy and safety profile after failure of 2GTKI. However, no study has specifically addressed response rates to asciminib in ponatinib pretreated patients (PPT). Here, we present data on responses to asciminib from 52 patients in clinical practice, 20 of them (38%) with prior ponatinib exposure. We analyzed retrospectively responses and toxicities under asciminib and compared results between PPT and non-PPT patients.After a median follow-up of 30 months, 34 patients (65%) switched to asciminib due to intolerance and 18 (35%) due to resistance to prior TKIs. Forty-six patients (88%) had received at least 3 prior TKIs. Regarding responses, complete cytogenetic response was achieved or maintained in 74% and 53% for non-PPT and PPT patients, respectively. Deeper responses such as major molecular response and molecular response 4.5 were achieved in 65% and 19% in non-PPT versus 32% and 11% in PPT, respectively. Two patients (4%) harbored the T315I mutation, both PPT.In terms of toxicities, non-PPT displayed 22% grade 3-4 TEAE versus 20% in PPT. Four patients (20% of PPT) suffered from cross-intolerance with asciminib as they did under ponatinib.Our data supports asciminib as a promising alternative in resistant and intolerant non-PPT patients, as well as in intolerant PPT patients; the resistant PPT subset remains as a challenging group in need of further therapeutic options.
PB Springer
YR 2022
FD 2022-08-23
LK http://hdl.handle.net/10668/19708
UL http://hdl.handle.net/10668/19708
LA en
NO Luna A, Pérez-Lamas L, Boque C, Giraldo P, Xicoy B, Ruiz Nuño C, et al. Real-life analysis on safety and efficacy of asciminib for ponatinib pretreated patients with chronic myeloid leukemia. Ann Hematol. 2022 Oct;101(10):2263-2270
DS RISalud
RD May 9, 2025