RT Journal Article T1 Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy A1 Bendala Estrada, Alejandro David A1 Calderon Parra, Jorge A1 Fernandez Carracedo, Eduardo A1 Muino Miguez, Antonio A1 Ramos Martinez, Antonio A1 Munez Rubio, Elena A1 Rubio-Rivas, Manuel A1 Agudo, Paloma A1 Arnalich Fernandez, Francisco A1 Estrada Perez, Vicente A1 Taboada Martinez, Maria Luisa A1 Crestelo Vieitez, Anxela A1 Pesqueira Fontan, Paula Maria A1 Bustamante, Marta A1 Freire, Santiago J. A1 Oriol-Bermudez, Isabel A1 Artero, Arturo A1 Olalla Sierra, Julian A1 Areses Manrique, Maria A1 Javier Carrasco-Sanchez, H. Francisco A1 Carolina Vento, Vanessa A1 Garcia Garcia, Gema Maria A1 Cubero-Morais, Pablo A1 Casas-Rojo, Jose-Manuel A1 Millan Nunez-Cortes, Jesus K1 COVID-19 K1 SARS-CoV-2 K1 Antibiotics K1 Survival K1 Macrolides K1 Azithromycin K1 Bacterial coinfection K1 Influenza K1 Infection K1 Adults K1 Sars-cov-2 K1 Guideline K1 Pneumonia K1 Virus AB Background Since December 2019, the COVID-19 pandemic has changed the concept of medicine. This work aims to analyze the use of antibiotics in patients admitted to the hospital due to SARS-CoV-2 infection. Methods This work analyzes the use and effectiveness of antibiotics in hospitalized patients with COVID-19 based on data from the SEMI-COVID-19 registry, an initiative to generate knowledge about this disease using data from electronic medical records. Our primary endpoint was all-cause in-hospital mortality according to antibiotic use. The secondary endpoint was the effect of macrolides on mortality. Results Of 13,932 patients, antibiotics were used in 12,238. The overall death rate was 20.7% and higher among those taking antibiotics (87.8%). Higher mortality was observed with use of all antibiotics (OR 1.40, 95% CI 1.21-1.62; p PB Bmc YR 2021 FD 2021-11-08 LK https://hdl.handle.net/10668/26563 UL https://hdl.handle.net/10668/26563 LA en DS RISalud RD Feb 24, 2025