RT Journal Article
T1 Residential Exposure to Outdoor Air Pollution during Pregnancy and Anthropometric Measures at Birth in a Multicenter Cohort in Spain
A1 Estarlich, Marisa
A1 Ballester, Ferran
A1 Aguilera, Inmaculada
A1 Fernández-Somoano, Ana
A1 Lertxundi, Aitana
A1 Llop, Sabrina
A1 Freire, Carmen
A1 Tardón, Adonina
A1 Basterrechea, Mikel
A1 Sunyer, Jordi
A1 Iñiguez, Carmen
K1 Emisiones de Vehículos
K1 Dióxido de Nitrógeno
K1 Benceno
K1 Contaminantes del Aire
K1 Adulto
K1 Peso al Nacer
K1 Tamaño Corporal
K1 Estudios de Cohortes
K1 Monitoreo del Ambiente
K1 Femenina
K1 Humanos
K1 Recién Nacido
K1 Recién Nacido Pequeño para la Edad Gestacional
K1 Exposición por Inhalación
K1 Exposición Materna
K1 Embarazo
K1 Estudios Prospectivos
K1 Questionnaires
K1 Distribución Espacial de la Población
K1 España
K1 Adulto Joven
K1 Air Pollution
K1 Anthropometry
K1 Benzene
K1 Birth
K1 Birth weight
K1 Nitrogen dioxide
K1 Pregnancy
AB BACKGROUND. A growing body of research suggests that prenatal exposure to air pollution may be harmful to fetal development. We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children's Health and Environment (INMA) mother and child cohort study. METHODS. Exposure to ambient nitrogen dioxide (NO2) and benzene was estimated for the residence of each woman (n = 2,337) for each trimester and for the entire pregnancy. Outcomes included birth weight, length, and head circumference. The association between residential outdoor air pollution exposure and birth outcomes was assessed with linear regression models controlled for potential confounders. We also performed sensitivity analyses for the subset of women who spent more time at home during pregnancy. Finally, we performed a combined analysis with meta-analysis techniques. RESULTS. In the combined analysis, an increase of 10 µg/m3 in NO2 exposure during pregnancy was associated with a decrease in birth length of -0.9 mm [95% confidence interval (CI), -1.8 to -0.1 mm]. For the subset of women who spent ≥ 15 hr/day at home, the association was stronger (-0.16 mm; 95% CI, -0.27 to -0.04). For this same subset of women, a reduction of 22 g in birth weight was associated with each 10-µg/m3 increase in NO2 exposure in the second trimester (95% CI, -45.3 to 1.9). We observed no significant relationship between benzene levels and birth outcomes. CONCLUSIONS. NO2 exposure was associated with reductions in both length and weight at birth. This association was clearer for the subset of women who spent more time at home.
PB National Institute of Environmental Health Sciences (NIEHS)
SN 0091-6765
YR 2011
FD 2011-09
LK http://hdl.handle.net/10668/575
UL http://hdl.handle.net/10668/575
LA en
NO Estarlich M, Ballester F, Aguilera I, Fernández-Somoano A, Lertxundi A, Llop S, et al. Residential exposure to outdoor air pollution during pregnancy and anthropometric measures at birth in a multicenter cohort in Spain. Environ. Health Perspect.. 2011 Sep; 119(9):1333-8
NO Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't. Reproduced with permission from Environmental Health Perspectives
DS RISalud
RD Apr 12, 2025