RT Journal Article
T1 Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease
A1 Muñoz-Castañeda, Juan Rafael
A1 Rodelo-Haad, Cristian
A1 Pendon-Ruiz de Mier, Maria Victoria
A1 Martin-Malo, Alejandro
A1 Santamaria, Rafael
A1 Rodriguez, Mariano
K1 FGFG23
K1 Klotho
K1 Wnt/B-catenin
K1 CKD
K1 Cardiorenal syndrome
K1 Klotho proteins
K1 Factores de crecimiento de fibroblastos
K1 Proteínas Wnt
K1 Vía de señalización Wnt
K1 Insuficiencia renal crónica
K1 Síndrome cardiorrenal
AB Fibroblast Growth Factor 23 (FGF23) and Klotho play an essential role in the regulation of mineral metabolism, and both are altered as a consequence of renal failure. FGF23 increases to augment phosphaturia, which prevents phosphate accumulation at the early stages of chronic kidney disease (CKD). This effect of FGF23 requires the presence of Klotho in the renal tubules. However, Klotho expression is reduced as soon as renal function is starting to fail to generate a state of FGF23 resistance. Changes in these proteins directly affect to other mineral metabolism parameters; they may affect renal function and can produce damage in other organs such as bone, heart, or vessels. Some of the mechanisms responsible for the changes in FGF23 and Klotho levels are related to modifications in the Wnt signaling. This review examines the link between FGF23/Klotho and Wnt/β-catenin in different organs: kidney, heart, and bone. Activation of the canonical Wnt signaling produces changes in FGF23 and Klotho and vice versa; therefore, this pathway emerges as a potential therapeutic target that may help to prevent CKD-associated complications.
PB MDPI
YR 2020
FD 2020-03-16
LK http://hdl.handle.net/10668/3725
UL http://hdl.handle.net/10668/3725
LA en
NO Muñoz-Castañeda JR, Rodelo-Haad C, Pendon-Ruiz de Mier MV, Martin-Malo A, Santamaria R, Rodriguez M. Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease. Toxins. 2020 Mar 16;12(3):185
DS RISalud
RD Apr 6, 2025