RT Journal Article
T1 A 5-Year Prospective Multicenter Evaluation of Influenza Infection in Transplant Recipients.
A1 Kumar, Deepali
A1 Ferreira, Victor H
A1 Blumberg, Emily
A1 Silveira, Fernanda
A1 Cordero, Elisa
A1 Perez-Romero, Pilar
A1 Aydillo, Teresa
A1 Danziger-Isakov, Lara
A1 Limaye, Ajit P
A1 Carratala, Jordi
A1 Munoz, Patricia
A1 Montejo, Miguel
A1 Lopez-Medrano, Francisco
A1 Farinas, Maria Carmen
A1 Gavalda, Joan
A1 Moreno, Asuncion
A1 Levi, Marilyn
A1 Fortun, Jesus
A1 Torre-Cisneros, Julian
A1 Englund, Janet A
A1 Natori, Yoichiro
A1 Husain, Shahid
A1 Reid, Gail
A1 Sharma, Tanvi S
A1 Humar, Atul
AB Seasonal influenza infection may cause significant morbidity and mortality in transplant recipients. The purpose of this study was to assess the epidemiology of symptomatic influenza infection posttransplant and determine risk factors for severe disease. Twenty centers in the United States, Canada, and Spain prospectively enrolled solid organ transplant (SOT) or hematopoietic stem cell transplant (HSCT) recipients with microbiologically confirmed influenza over 5 consecutive years (2010-2015). Demographics, microbiology data, and outcomes were collected. Serial nasopharyngeal swabs were collected at diagnosis and upto 28 days, and quantitative polymerase chain reaction for influenza A was performed. We enrolled 616 patients with confirmed influenza (477 SOT; 139 HSCT). Pneumonia at presentation was in 134 of 606 (22.1%) patients. Antiviral therapy was given to 94.1% for a median of 5 days (range, 1-42 days); 66.5% patients were hospitalized and 11.0% required intensive care unit (ICU) care. The receipt of vaccine in the same influenza season was associated with a decrease in disease severity as determined by the presence of pneumonia (odds ratio [OR], 0.34 [95% confidence interval {CI}, .21-.55], P  Annual influenza vaccination and early antiviral therapy are associated with a significant reduction in influenza-associated morbidity, and should be emphasized as strategies to improve outcomes of transplant recipients.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/12327
UL http://hdl.handle.net/10668/12327
LA en
DS RISalud
RD Apr 11, 2025