RT Generic
T1 Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy
A1 Kazantseva, Liliya
A1 Becerra, Jose
A1 Santos-Ruiz, Leonor
K1 osteosarcoma
K1 natural products
K1 traditional medicinal plants
K1 drug discovery
K1 signaling pathway
K1 combination therapy
K1 Nf-kappa-b
K1 Autophagic cell-death
K1 Breast-cancer cells
K1 Signaling pathway
K1 Natural inhibitor
K1 Lung-cancer
K1 Apoptosis
K1 Triptolide
K1 Parthenolide
K1 Proliferation
AB Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably high. The standard drug combination used to treat this bone cancer has remained the same for the last 20 years, and it produces many dangerous side effects. Through history, from ancient to modern times, nature has been a remarkable source of chemical diversity, used to alleviate human disease. The application of modern scientific technology to the study of natural products has identified many specific molecules with anti-cancer properties. This review describes the latest discovered anti-cancer compounds extracted from traditional medicinal plants, with a focus on osteosarcoma research, and on their cellular and molecular mechanisms of action. The presented compounds have proven to kill osteosarcoma cells by interfering with different pathways: apoptosis induction, stimulation of autophagy, generation of reactive oxygen species, etc. This wide variety of cellular targets confer natural products the potential to be used as chemotherapeutic drugs, and also the ability to act as sensitizers in drug combination treatments. The major hindrance for these molecules is low bioavailability. A problem that may be solved by chemical modification or nano-encapsulation.
PB Mdpi
YR 2022
FD 2022-08-01
LK http://hdl.handle.net/10668/21439
UL http://hdl.handle.net/10668/21439
LA en
DS RISalud
RD Apr 5, 2025