RT Journal Article
T1 Indole Tryptophan Metabolism and Cytokine S100B in Children with Attention-Deficit/Hyperactivity Disorder: Daily Fluctuations, Responses to Methylphenidate, and Interrelationship with Depressive Symptomatology.
A1 Fernández-López, Luisa
A1 Molina-Carballo, Antonio
A1 Cubero-Millán, Isabel
A1 Checa-Ros, Ana
A1 Machado-Casas, Irene
A1 Blanca-Jover, Enrique
A1 Jerez-Calero, Antonio
A1 Madrid-Fernández, Yolanda
A1 Uberos, José
A1 Muñoz-Hoyos, Antonio
K1 ADHD
K1 S100B protein
K1 daily rhythms
K1 depressive symptoms
K1 indole tryptophan metabolites
K1 methylphenidate
AB Background: Indole tryptophan metabolites (ITMs), mainly produced at the gastrointestinal level, participate in bidirectional gut-brain communication and have been implicated in neuropsychiatric pathologies, including attention-deficit/hyperactivity disorder (ADHD). Method: A total of 179 children, 5-14 years of age, including a healthy control group (CG, n = 49), and 107 patients with ADHD participated in the study. The ADHD group was further subdivided into predominantly attention deficit (PAD) and predominantly hyperactive impulsive (PHI) subgroups. Blood samples were drawn at 20:00 and 09:00 hours, and urine was collected between blood draws, at baseline and after 4.63 ± 2.3 months of methylphenidate treatment in the ADHD group. Levels and daily fluctuations of ITM were measured by tandem mass spectrometer, and S100B (as a glial inflammatory marker) by enzyme-linked immunosorbent assay. Factorial analysis of variance (Stata 12.0) was performed with groups/subgroups, time (baseline/after treatment), hour of day (morning/evening), and presence of depressive symptoms (DS; no/yes) as factors. Results: Tryptamine and indoleacetic acid (IAA) showed no differences between the CG and ADHD groups. Tryptamine exhibited higher evening values (p 
YR 2020
FD 2020-02-12
LK http://hdl.handle.net/10668/15088
UL http://hdl.handle.net/10668/15088
LA en
DS RISalud
RD Mar 14, 2025